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131R-2

Sigma-Aldrich

CD31 (EP78) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP78, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (131R-27)
bottle of 7.0 mL predilute (131R-28)
vial of 0.1 mL concentrate (131R-24)
vial of 0.5 mL concentrate (131R-25)
vial of 1.0 mL concentrate (131R-26)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... PECAM1(5175)

Related Categories

General description

CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Endothelial cells also express this marker; therefore, antibodies to CD31 have been used as a tool to identify the vascular origin of neoplasms.1-3 Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells.4 Staining of nonvascular tumors (excluding hematopoietic neoplasms) has not been observed.

Quality


IVD
IVD
IVD
RUO

Linkage

CD31 Positive Control Slides, Product No. 131S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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F Alexander-Sefre et al.
Journal of clinical pathology, 56(10), 786-788 (2003-09-30)
Lymphovascular space invasion (LVSI) is an important step in the complex process of tumour metastasis. Various methods have been used in the past to improve the histological detection of LVSI. To develop a sensitive immunohistochemical method for the detection of
B R De Young et al.
American journal of clinical pathology, 110(3), 374-377 (1998-09-05)
CD31 is a specific and sensitive marker of endothelial differentiation. Previous reports have described its immunoreactivity in large series of soft tissue neoplasms, as well as its comparison with other available and commonly used endothelial markers. CD31 reactivity in carcinomas
D V Parums et al.
Journal of clinical pathology, 43(9), 752-757 (1990-09-01)
A new monoclonal antibody, JC70, raised against a membrane preparation from a spleen affected by hairy cell leukaemia, recognises a membrane bound glycoprotein identical with that of the CD31 group of monoclonal antibodies. The antibody stains a fixation resistant epitope
J U Alles et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 34(2), 209-214 (1986-02-01)
A new monoclonal antibody (moab BW 200) of IgG3 kappa-isotype was generated which recognizes an epitope located on an antigen molecule restricted to human neoplastic and non-neoplastic endothelial cells. The molecular weight of the antigen was determined using immunoprecipitation analysis

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