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M4125

Sigma-Aldrich

D-Mannitol

≥98% (GC)

Synonym(s):

Mannite

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10 MG
175,00 kr.
100 G
350,00 kr.
500 G
620,00 kr.
1 KG
1.300,00 kr.
5 KG
4.400,00 kr.

175,00 kr.

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10 MG
175,00 kr.
100 G
350,00 kr.
500 G
620,00 kr.
1 KG
1.300,00 kr.
5 KG
4.400,00 kr.

About This Item

Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
69-65-8
Molecular Weight:
182.17
Beilstein:
1721898
EC Number:
200-711-8
MDL number:
MFCD00064287
UNSPSC Code:
12352201
PubChem Substance ID:
24896902
NACRES:
NA.21

175,00 kr.

Please contact Customer Service for Availability
Request a Bulk Order

biological source

plant

Quality Level

200

Assay

≥98% (GC)

form

powder

color

white

useful pH range

5.0-6.5 (25 °C, 182 g/L, (77 °F ))

mp

167-170 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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General description

D-Mannitol, a naturally occurring six-carbon sugar alcohol or polyol, is found in plants such as algae, onions, grasses, and olives. It is considered safe due to its relatively lower glycemic index than sucrose.

Application

D-Mannitol has been used:
  • in osmotic loading to adjust the osmolarity of solutions
  • as a component of test sugar solution for cellobiose-mannitol permeability test
  • as an internal standard in nuclear magnetic resonance (NMR) to compare/analyze the mannitol concentrations in urine samples
  • to treat the control cells and regulate the osmotic pressure of high glucose

D-mannitol has been used as a hydroxyl radical scavenger and as a medium supplement.[1][2]

Biochem/physiol Actions

D-Mannitol may play an important role in lipolysis and fat oxidation as it can enhance the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase 1 (ACC). It serves as an anti-obesity supplement. D-Mannitol stimulates the synthesis of short-chain fatty acids (SCFAs), which regulate lipid metabolism in the liver.
A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Other Notes

To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000411916
0000411578
0000411578
0000387703
0000387703

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S J Upton et al.
Journal of clinical microbiology, 33(2), 371-375 (1995-02-01)
Surface-sterilized oocysts of Cryptosporidium parvum were applied to subconfluent monolayers of human adenocarcinoma (HCT-8) cells grown on coverslips in six-well cluster plates. Parasite-infected cultures were then incubated in RPMI 1640 with 10% fetal bovine serum, 15 mM HEPES (N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid)
A Matsuzaki et al.
Cancer research, 49(20), 5702-5707 (1989-10-15)
Rat 3Y1 fibroblasts transformed by the E1A gene of adenovirus type 12 (E1A-3Y1 cells) are highly sensitive to the cell-killing effect of 1,3-dilinoleoylglycerol (DLG) administered in a culture medium, whereas the parental 3Y1 cells are less sensitive (H. Shimura et
Heikki O Koskela et al.
Chest, 125(6), 1985-1992 (2004-06-11)
To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded
Diana Bilton et al.
Thorax, 69(12), 1073-1079 (2014-09-24)
Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic
Pär Matsson et al.
Journal of medicinal chemistry, 48(2), 604-613 (2005-01-22)
The influence of different drug transport routes in intestinal drug permeability screening assays was studied. Three experimental models were compared: the small-intestine-like 2/4/A1 cell model, which has a leaky paracellular pathway, the Caco-2 cell model, which has a tighter paracellular
View All Related Papers

Questions

1–6 of 6 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. What is the particle size on this product? Looking for a larger particle size 100-250um

    1 answer

    1. Unfortunately, the particle size is not determined for this product.

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  4. IS IT TESTED ON ANIMAL CELL CULTURE

    1 answer

    1. This product has not been tested with mammalian cell culture. It is cited to have been used in primary retinal cell culture.
      Kindly review the following publication: Trotta MC, Pieretti G, Petrillo F, Alessio N, Hermenean A, Maisto R, D'Amico M. Resolvin D1 reduces mitochondrial damage to photoreceptors of primary retinal cells exposed to high glucose. J Cell Physiol. 2020 May;235(5):4256-4267. doi: 10.1002/jcp.29303. Epub 2019 Oct 14. PMID: 31612492.

      In addition, product M1902 has been tested for use in plant culture and product 63560 has been tested for use in microbiology. See the links below to review each product.
      M1902
      https://www.sigmaaldrich.com/product/sigma/m1902
      63560
      https://www.sigmaaldrich.com/product/sial/63560

      Helpful?

  5. Hi! Is this product safe to use in studies for animals?

    1 answer

    1. This product is intended for research use only. Currently, no D-Mannitol product is offered that is tested for in vivo or in vitro use.
      For use in animal models, product M8429 may be a more suitable option. While still a research-grade reagent, this product meets USP, EP, and FCC specifications.

      Please see the link below to review this product option:
      https://www.sigmaaldrich.com/product/sial/m8429

      In either case, the end user would have to determine suitability.

      Helpful?

  6. I have a question about mannitol (as an excipient in a medicinal product). The questions would be the following: Is mannitol absorbed at intestinal level? Do you know about a possible interaction between mannitol and disulfiram? Thank you.

    1 answer

    1. Please note, unless otherwise stated, this product is intended for research purposes only and not for use as a drug to be administered to animals or humans.
      The in vivo metabolism of this product has not been evaluated. However, certain publications show that mannitol is absorbed by the small intestine.
      The link below may provide helpful information:
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802677/

      Helpful?

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