17929
O-Methyl-O′-succinylpolyethylene glycol 5′000
Synonym(s):
Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 5′000, Polyethylene glycol 5000 monomethyl ether succinate
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About This Item
Linear Formula:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS Number:
MDL number:
UNSPSC Code:
51171641
NACRES:
NA.26
Recommended Products
form
powder
mol wt
Mr ~5100
mp
56-60 °C
Ω-end
carboxylic acid
α-end
methoxy
storage temp.
−20°C
Application
Polyethylene glycol 5000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.
Soluble polymer for solid phase synthesis of imines and β-lactams; attaching peptides to PEG
Biochem/physiol Actions
O-Methyl-O′-succinylpolyethylene glycol 5′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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A Bogdanov et al.
Journal of drug targeting, 4(5), 321-330 (1997-01-01)
A co-polymer of O-methyl polyethylene(glycol)-O'-succinate (MPEGs, m.w. 5100) and poly-l-lysine (PL, median m.w. 32700, degree of polymerization 256) has been synthesized by covalent grafting. The resultant MPEGs-PL (30% modification degree of epsilon-amino groups) had a hydrodynamic diameter corresponding to a
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Journal of nanoscience and nanotechnology, 9(8), 5091-5098 (2009-11-26)
Hydrophobic drugs, loperamide and paclitaxel, were loaded in poly(butyl cyanoacrylate) nanoparticles by polymerization of n-butyl-2-cyanoacrylate in aqueous-organic media in the presence of a drug. The particles were stabilized by dextran 70,000 and poloxamer 188 or by 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] sodium salt.
Mario Beyer et al.
Methods in molecular biology (Clifton, N.J.), 570, 309-316 (2009-08-04)
Combinatorial synthesis of peptides on solid supports (1), either as spots on cellulose membranes (2) or with split-pool-libraries on polymer beads (3), substantially forwarded research in the field of peptide-protein interactions. Admittedly, these concepts have specific limitations, on one hand
Peter M Fischer et al.
Journal of peptide science : an official publication of the European Peptide Society, 8(9), 529-542 (2002-10-10)
Stepwise synthetic assembly of polypeptide chains reversibly linked to polyethylene glycol represents a hybrid between traditional solution and solid-phase chemistries and combines the inherent advantages of both approaches. The technical simplicity and scalability of the liquid-phase peptide synthesis method renders
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Kanjiro Miyata (The University of Tokyo, Japan) provides insights on the rational design of polymeric materials for “smart” oligonucleotide delivery.
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