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MABN92-AF488

Sigma-Aldrich

Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor™ 488 Conjugate

clone 20A12.1, from mouse, ALEXA FLUOR™ 488

Synonym(s):

Allograft inflammatory factor 1, AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.45

biological source

mouse

Quality Level

100

conjugate

ALEXA FLUOR™ 488

antibody form

purified antibody

antibody product type

primary antibodies

clone

20A12.1, monoclonal

species reactivity

human, mouse, rat

technique(s)

immunohistochemistry: suitable

isotype

IgG1κ

NCBI accession no.

NP_001614

UniProt accession no.

P55008

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... AIF1(199)

General description

Allograft inflammatory factor 1 (UniProt P55008; also known as AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1) is encoded by the AIF1 (also known as G1, IBA1) gene (Gene ID 199) in human. Iba1/AIF1 is a 17 kDa interferon-gamma- (IFN-gamma-) inducible, Ca(2+)-binding EF-hand protein. Iba1/AIF1 expression is mostly limited to the macrophage/monocyte lineage, and is augmented by cytokines, such as IFN-gamma. It is reported to be involved in neuronal function, inflammatory responses, allograft rejection, autoimmunity, and macrophage activation/function. It is also shown to be expressed in microglial cells in autominnume disesase models such as experimental autoimmune encephalomyelitis, neuritis and uveitis.

Application

Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor™ 488 Conjugate is an antibody against Iba1/AIF1 for use in Immunohistochemistry.

Quality

Evaluated by Immunohistochemistry in human spleen tissue.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected Iba1/AIF1 in human spleen tissue.

Target description

~17 kDa observed

Other Notes

Concentration: Please refer to lot specific datasheet.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hao-Cheng Chang et al.
The Journal of biological chemistry, 299(1), 102728-102728 (2022-11-22)
Haploinsufficiency in retinoic acid induced 1 (RAI1) causes Smith-Magenis syndrome (SMS), a severe neurodevelopmental disorder characterized by neurocognitive deficits and obesity. Currently, curative treatments for SMS do not exist. Here, we take a recombinant adeno-associated virus (rAAV)-clustered regularly interspaced short

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