LAR-interacting protein 1, LIP-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, PTPRF-interacting protein alpha-1
Liprin-alpha-1 (UniProt: Q13136; also known as LAR-interacting protein 1, LIP-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, PTPRF-interacting protein alpha-1) is encoded by the PPFIA1 (also known as LIP1) gene (Gene ID: 8500) in human. Liprin-alpha-1 is a member of the LAR (leukocyte common antigen-related) protein tyrosine phosphatase-interacting protein (liprin) family. It is a cytoplasmic protein that regulates the disassembly of focal adhesions. It forms homodimers and heterodimers with Liprin-alpha and Liprin-beta. Liprins contain an N-terminal coiled-coil domain and a C-terminal liprin homology (LH) region comprised of three sterile alpha motif (SAM) domains. The N-terminal region acts as a binding region for several synaptic proteins. SAM domain are known to bind to both protein kinases and phosphatases. In mast cells, liprin-alpha-1 facilitates exocytosis and cell spreading.
Specificity
This polyclonal antibody detects Liprin Alpha 1 in human. It targets an epitope within 179 amino acids from the internal region of isoform 1 and 2.
Immunogen
GST-tagged recombinant fragment of 179 amino acids from the internal region of human Liprin Alpha 1.
Application
Research Category Cell Structure
This rabbit polyclonal Anti-Liprin Alpha 1, Cat. No. ABT268 detects Liprin alpha 1 in human cells. It has been tested for use in Western Blotting.
Quality
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Liprin Alpha 1 in 10 µg of HeLa cell lysate.
Target description
~160 kDa observed; 135.78 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physical form
Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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