07-104

Anti-IGF2 mRNA-binding protein 3 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): IGF II mRNA binding protein 3, IGF-II mRNA-binding protein 3, IGF2 mRNA-binding protein 3, KH domain containing protein overexpressed in cancer, KH domain-containing protein overexpressed in cancer, VICKZ family member 3, insulin-like growth factor 2 mRN
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human, mouse, canine
• species reactivity (predicted by homology): rhesus monkey (based on 100% sequence homology), dog (based on 100% sequence homology), horse (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• technique(s): western blot: suitable
• NCBI accession no.: NP_006538
• UniProt accession no.: O00425
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... IGF2BP3(10643)

Description

General description

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5′ UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq].

Specificity

This antibody recognizes IGF2 mRNA-binding protein 3 at the C-terminus.

Immunogen

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to human IGF2 mRNA-binding protein 3 at and around the C-terminus.

Application

Research Category
Apoptosis & Cancer

Research Sub Category
Growth Factors & Receptors

This Anti-IGF2 mRNA-binding protein 3 Antibody is validated for use in WB for the detection of IGF2 mRNA-binding protein 3.

Western Blot (SNAP ID) Analysis: 2 µg/mL from a previous lot detected IGF2 mRNA-binding protein 3 on 10 µg of Hek293 cell lysate.

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP.

Quality

Evaluated by Western Blot in Hek293 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IGF2 mRNA-binding protein 3 on 10 µg of Hek293 cell lysate.

Target description

64 kDa was observed. Predicted to cross-react with all the Isoforms of IGF2BP3.

Physical form

Affinity purified

Purified rabbit serum in PBS with 0.09% azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Hek293 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable