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760978

Sigma-Aldrich

Poly(N-isopropylacrylamide) triethoxysilane terminated

average Mn 5,000

Synonym(s):

PNIPAM silane, polyNIPAM surface modifier

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About This Item

Linear Formula:
(C6H11NO)nSCH2CH2CH2Si(OCH2CH3)3
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

mol wt

average Mn 5,000

PDI

≤2.5

storage temp.

2-8°C

General description

Poly(N-isopropylacryamide) (PNIPAAm) is a thermoresponsive polymer. It is soluble in water below its lower critical solution temperature (LCST) (32°C) whereas it forms intramolecular hydrogen bonds thus becoming insoluble at temperatures above its LCST. PNIPAAm is functionalized with a silane coupling agent like triethoxysilane in order to reduce its surface energy thus making it hydrophobic. Triethoxysilane terminated PNIPAAm thus exhibits a switchable superhydrophobic/hydrophilic surface and are widely used as hydrophobic valves in microfluidic channels.

Application

  • Used in the synthesis of microspheres which are used in drug-delivery systems.
  • Used in fluidic devices, in protein affinity separation, and as cell culture substrates.

Features and Benefits

It exhibits swelling or deswelling behaviour with respect to external temperature which favours in nucleic acid adsorption and drug release applications.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Poly(N-isopropylacrylamide) Mn ~40,000

Sigma-Aldrich

535311

Poly(N-isopropylacrylamide)

N-Isopropylacrylamide 97%

Sigma-Aldrich

415324

N-Isopropylacrylamide

Qiang He et al.
Langmuir : the ACS journal of surfaces and colloids, 23(7), 3981-3987 (2007-02-24)
Micro- and nanopatterns of thermosensitive poly(N-isopropylacrylamide) brush on gold substrate were prepared by using chemical lithography combined with surface-initiated atom transfer radical polymerization. Self-assembled monolayers of 4'-nitro-1, 1'-biphenyl-4-thiol were structured by chemical lithography which produced cross-linked 4'-amino-1,1'-biphenyl-4-thiol monolayer within a
Poly (N-isopropylacrylamide)-coated luminescent/magnetic silica microspheres: preparation, characterization, and biomedical applications
Guo, J., Yang, W., Wang, C., He, J., & Chen, J.
Chemistry of Materials, 18(23), 5554-5562 (2006)
Conformal switchable superhydrophobic/hydrophilic surfaces for microscale flow control.
Chunder, A., Etcheverry, K., Londe, G., Cho, H. J., & Zhai, L.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 333(1), 187-193 (2009)

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