222909
N-Phenylthiourea
97%
Synonym(s):
1-Phenyl-2-thiourea, PTU, Phenylthiocarbamide
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About This Item
Linear Formula:
C6H5NHCSNH2
CAS Number:
Molecular Weight:
152.22
Beilstein:
907309
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Assay
97%
mp
145-150 °C (lit.)
SMILES string
NC(=S)Nc1ccccc1
InChI
1S/C7H8N2S/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
InChI key
FULZLIGZKMKICU-UHFFFAOYSA-N
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Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Oral - Skin Sens. 1
Storage Class Code
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Anna A Brozyna et al.
International journal of cancer, 123(6), 1448-1456 (2008-06-21)
Melanin pigment displays strong photo- and radioprotective properties, suggesting that inhibition melanogenesis could increase sensitivity of melanoma to ionizing radiation. We tested this concept in human melanoma cells cultured in either Ham's F10 medium to maintain amelanotic phenotype or DMEM
Xiangguo Shi et al.
Blood, 125(19), 2974-2984 (2015-03-18)
Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2. However, the
Warrick J Brewer et al.
Psychiatry research, 199(1), 8-11 (2012-04-17)
Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to controls have recently been controversial. If supported, a genetic-based phenotypic variation in PTC taster status is implicated, suggesting a greater illness risk for those
Laila Gannoun-Zaki et al.
Antimicrobial agents and chemotherapy, 57(1), 629-632 (2012-11-02)
The mechanism by which the antitubercular drug isoxyl (ISO) inhibits mycolic acid biosynthesis has not yet been reported. We found that point mutations in either the HadA or HadC component of the type II fatty acid synthase (FAS-II) are associated
Thomas Grau et al.
Antimicrobial agents and chemotherapy, 56(2), 1142-1145 (2011-11-23)
Ethionamide (ETH) is a second-line drug for the treatment of tuberculosis. As a prodrug, ETH has to be activated by EthA. ethA is controlled by its repressor EthR. 2-Phenylethyl-butyrate (2-PEB) inhibits EthR binding, enhances expression of EthA, and thereby enhances
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