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U4625

Sigma-Aldrich

Uridine 5′-diphosphoglucose disodium salt hydrate from Saccharomyces cerevisiae

≥98%

Synonym(s):

UDP-Glc hydrate, UDPG hydrate

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About This Item

Empirical Formula (Hill Notation):
C15H22N2Na2O17P2 · xH2O
CAS Number:
Molecular Weight:
610.27 (anhydrous basis)
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

biological source

Saccharomyces cerevisiae

Quality Level

Assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].OC[C@H]1O[C@H](OP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C15H24N2O17P2.2Na.H2O/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25;;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25);;;1H2/q;2*+1;/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14-;;;/m1.../s1

InChI key

SRHFBUUOPANXBG-WSIJJEQHSA-L

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General description

Uridine diphosphate glucose (UDP-glucose) is a glycogen precursor. The transfer of glucose from UDP-glucose to growing glycogen chain is catalyzed by the enzyme glycogen synthase. The enzyme uridine diphosphate galactose-4-epimerase catalyzes the formation of UDP-glucose from UDP-galactose.

Application

Uridine 5′-diphosphoglucose disodium salt hydrate from Saccharomyces cerevisiae has been used as a substrate
  • for the PpIRX10 enzyme activity from Arabidopsis thaliana
  • in radiometric assay of glycosyltransferases (GTs)
  • in uridine diphosphate glucose (UDP-Glc) 4-epimerase assay in Arabidopsis thaliana samples

Biochem/physiol Actions

Uridine diphosphate glucose (UDP-glucose) is an essential mediator of the cellular metabolic pathways. In yeast, the high levels of trehalose and glycogen favor increased levels of UDP-glucose.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Unravelling evolutionary strategies of yeast for improving galactose utilization through integrated systems level analysis
Hong KK, et al.
Proceedings of the National Academy of Sciences of the USA, 108(29), 12179-12184 (2011)
Hypoglycemia as a Pathological Result in Medical Praxis
Type 1 Diabetes Complications (2011)
Fariborz Parandeh et al.
The Journal of biological chemistry, 295(45), 15245-15252 (2020-08-29)
Type-2 diabetes (T2D) is a global disease caused by the inability of pancreatic β-cells to secrete adequate insulin. However, the molecular mechanisms underlying the failure of β-cells to respond to glucose in T2D remains unknown. Here, we investigated the relative
Distinct properties of the five UDP-D-glucose/UDP-D-galactose 4-epimerase isoforms of Arabidopsis thaliana
Barber C, et al.
The Journal of Biological Chemistry, 281(25), 17276-17285 (2006)
A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolism
Fuhring J, et al.
Scientific Reports, 5, 9618-9618 (2015)

Articles

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

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