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F9786
Fibroblast Growth Factor-Basic Heparin Stabilized human
recombinant, expressed in E. coli, aqueous solution, suitable for cell culture
Synonym(s):
rhbFGF
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Product Name
Fibroblast Growth Factor-Basic Heparin Stabilized human, FGF-Basic, recombinant, expressed in E. coli, sterile-filtered, aqueous solution, suitable for cell culture
biological source
human
Quality Level
recombinant
expressed in E. coli
sterility
sterile-filtered
form
aqueous solution
potency
0.03-3.0 ng/mL ED50/EC50
quality
endotoxin tested
packaging
pkg of 1 and 5 mL
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... FGF2(2247)
General description
Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.[1]
Application
Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV).[2] It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.[3]
Biochem/physiol Actions
Fibroblast growth factor 2 (FGF2) participates in tissue development and repair.[1] It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system.[4] FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor.[1] bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types.[4] In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion.[5] It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.
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Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Fibroblast growth factors in cell culture and various growth factors for your research
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