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Sigma-Aldrich

MMP Inhibitor I

The MMP Inhibitor I controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

MMP Inhibitor I, FN-439

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About This Item

Empirical Formula (Hill Notation):
C23H34N6O6
Molecular Weight:
490.55
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

solid

potency

1 μM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A tetrapeptidyl hydroxamic acid that inhibits MMP-1 and MMP-8 (IC50 = 1.0 µM), MMP-9 (IC50 = 30 µM) and MMP-3 (IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. Nos. 53702 or 537088) or human granulocyte elastase.
A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. No. 53702) or human neutrophil elastase.

Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-1, MMP-8
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jörg Weiske et al.
Methods in molecular biology (Clifton, N.J.), 289, 175-192 (2004-10-27)
In epidermal cells desmosomes represent major sites of basolateral cell-cell contacts that play an important role for epidermal homeostasis. Excess or damaged cells are often removed by apoptosis. To release apoptotic cells from the tissue, intercellular contacts have to be

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