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805092

Sigma-Aldrich

PLGA nanoparticles

100 nm average diameter

Synonym(s):

Degradex® PLGA, poly(D,L-lactide-co-glycolide)

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About This Item

Linear Formula:
HO(C3H4O2)x(C2H2O2)yH
UNSPSC Code:
12162002
NACRES:
NA.23
Pricing and availability is not currently available.

form

powder

Quality Level

100

average diameter

100 nm

density

1.3 g/cm3

shipped in

wet ice

storage temp.

−20°C

Related Categories

General description

Degradex® is made with poly(D,L-lactide-co-glycolide) with an L/G ratio of 50/50 and a Mw of 30,000.
To re-constitute:
  • Remove the product from freezer.
  • Wait until temperature rises to the ambient temperature.
  • Add DI water or buffer to the container.
  • Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended.
The particle size of the PLGA nanoparticles are closely dependent on both the nature and concentration of the stabilizer and polymer.[1][2]

Application

Plain PLGA particles can be used for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery.A study reports the use of PLGA nanoparticles as estrogen carriers. The carrier-drug system was prepared by emulsification-diffusion method.[1][2]

Legal Information

Degradex is a registered trademark of Phosphorex, Inc.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX0810
MKCW1688
MKCT2852
MKCT9440
MKCR7346

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Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method
Kwon HY, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 182(1-3), 123-130 (2001)
The Characteristics and Mechanisms of Uptake of PLGA Nanoparticles in Rabbit Conjunctival Epithelial Cell Layers
Qaddoumi MG, et al.
Pharmaceut. Res., 21(4), 641-648 null

Articles

Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development

Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.

Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development

Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.

Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development

Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.

Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development

Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.

See All

Questions

  1. Need more info on how to use the particles: How long are the PLGA nanoparticles stable for once reconstituted in water/PBS? Is 20mg/ml a good concentration to resuspend at? Presumably they should be stored at 4°C instead of refrozen once reconstituted?

    1 answer

    1. The stability of the PLGA nanoparticles in the solution is not determined. However, various sources state that suspensions may be stable for greater than 2 weeks in aqueous buffers when stored at 4°C. See the link below for preparation and surface conjugation instructions. Allow the product to reach room temperature before suspending it in water or buffer. Suspensions may require vertexing or sonication:
      https://www.sigmaaldrich.com/technical-documents/technical-article/materials-science-and-engineering/drug-delivery/egradex-microspheres-nanoparticles

      It may be helpful to review the additional publications below:
      https://pubs.acs.org/doi/pdf/10.1021/acs.macromol.0c00110

      Helpful?

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