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  • Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats.

Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats.

International journal of molecular medicine (2001-10-18)
J Cancelas, M L Villanueva-Peñacarrillo, I Valverde, W J Malaisse
ABSTRACT

The dimethyl ester of L-glutamic acid (DMG) stimulates insulin release and was proposed as a possible insulinotropic tool in the treatment of non-insulin-dependent diabetes. In such a perspective, it was investigated whether DMG enhances the B-cell secretory response to GLP-1 in fed anaesthetized rats. The primed constant infusion of DMG (1.0 micromol and then 0.5 micromol/min, both per g body wt.) provoked a rapid and sustained increase in plasma insulin concentration and augmented the release of insulin caused by GLP-1. Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
L-Glutamic acid dimethyl ester hydrochloride, ≥99.0% (anhydrous basis material, AT)
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