SRP8028

DR6 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

• Synonym(s): CD358, TNFRSF21, Tumor necrosis factor receptor superfamily member 21
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in HEK 293 cells
• Assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~80 kDa by SDS-PAGE
• packaging: pkg of 50 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: <0.1 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: O75509
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... TNFRSF21(27242)

Description

General description

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 μL deionized water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.

Other Notes

The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable