SRP6333

CD74 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(s): DHLAG, HLA class II histocompatibility antigen gamma chain isoform b, HLADG, Ia-GAMMA
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• Assay: ≥90% (SDS-PAGE)
• form: liquid
• mol wt: 20.6 kDa (183 aa, 73-232 aa + His tag)
• packaging: pkg of 100 μg
• concentration: 0.5 mg/mL
• impurities: <1 EU/μg endotoxin (LAL test)
• UniProt accession no.: P04233
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... CD74(972)

Description

General description

HLA class II histocompatibility antigen gamma chain isoform b, also known as CD74, is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. It is upregulated in several cancers and is also expressed by nonimmune cells during inflammation. Recombinant human CD74 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl, 1 mM DTT and 30% glycerol.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable