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SML2786

Sigma-Aldrich

WRG-28

≥98% (HPLC)

Synonym(s):

DDR2 inhibitor WRG-28, N-Ethyl-4-[[(3-oxo-3H-phenoxazin-7-yl)oxy]methyl]-benzenesulfonamide

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€70.60
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€285.00

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5 MG
€70.60
25 MG
€285.00

About This Item

Empirical Formula (Hill Notation):
C21H18N2O5S
CAS Number:
1913291-02-7
Molecular Weight:
410.44
MDL number:
MFCD32201040
UNSPSC Code:
12352200
NACRES:
NA.77

€70.60

In StockDetails

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to very dark orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NCC)c1ccc(cc1)COc2cc3[o]c4c(nc3cc2)cc[c](c4)=O

InChI key

AARVTLIQNGAELZ-UHFFFAOYSA-N

Biochem/physiol Actions

WRG-28 is a potent, selective and extracellularly acting allosteric inhibitor of discoidin domain receptor 2 (DDR2) that potently inhibits invasion and migration in mice model of breast cancer. WRG-28 inhibits metastatic breast tumor cell colonization in the lungs.
potent, selective and extracellularly acting allosteric inhibitor of DDR2 that potently inhibits invasion and migration tumor cells

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000120695
0000120694
0000112363

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Pengwei Lu et al.
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Belinostat is a histone deacetylase inhibitor drug capable of regulating cell growth in diverse cancers. Nonetheless, little information clarified the role of Belinostat in breast cancer. Hence, the functions of Belinostat in breast cancer cells survival was disclosed in this
Saumya S Gurbani et al.
Tomography (Ann Arbor, Mich.), 5(1), 53-60 (2019-03-12)
Histone deacetylases regulate a wide variety of cellular functions and have been implicated in redifferentiation of various tumors. Histone deacetylase inhibitors (HDACi) are potential pharmacologic agents to improve outcomes for patients with gliomas. We assessed the therapeutic efficacy of belinostat
Priscilla Y Hwang et al.
Cancer research, 79(8), 1899-1912 (2019-03-14)
Collective cell migration is an adaptive, coordinated interactive process involving cell-cell and cell-extracellular matrix (ECM) microenvironmental interactions. A critical aspect of collective migration is the sensing and establishment of directional movement. It has been proposed that a subgroup of cells
Francesco Marampon et al.
Cancer letters, 461, 90-101 (2019-07-22)
This study describes the in vitro and in vivo activity of PXD-101 (Belinostat), a novel hydroxamic acid-type pan-HDACs inhibitor characterized by a larger safety and efficacy, on myogenic-derived PAX3/FOXO1 fusion protein positive (RH30) or negative (RD) expressing rhabdomyosarcoma (RMS) cell
Wen Chiy Liew et al.
The Journal of allergy and clinical immunology, 146(3), 606-620 (2020-02-24)
Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Skin barrier defects contribute to disease initiation and development; however, underlying mechanisms remain elusive. To understand the underlying cause of barrier defect, we investigated aberrant expression of specific microRNAs (miRNAs)
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