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SMB00807

Sigma-Aldrich

Glycolithocholate sulfate

≥95% (HPLC)

Synonym(s):

Glycolithocholic acid 3-sulfate, Sulfoglycolithocholic acid, Sulfolithocholylglycine

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About This Item

Empirical Formula (Hill Notation):
C26H43NO7S
CAS Number:
15324-64-8
Molecular Weight:
513.69
UNSPSC Code:
41141802
NACRES:
NA.28

Assay

≥95% (HPLC)

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C26H43NO7S/c1-16(4-9-23(28)27-15-24(29)30)20-7-8-21-19-6-5-17-14-18(34-35(31,32)33)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22H,4-15H2,1-3H3,(H,27,28)(H,29,30)(H,31,32,33)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1

InChI key

FHXBAFXQVZOILS-OETIFKLTSA-M

General description

Sulfoglycolithocholic acid, also known as sulfolithocholylglycine, belongs to the class of compounds referred as glycinated bile acids and derivatives. This compound serves as a valuable asset in both biochemical and metabolomics research due to its significant role in the field of bile acid conjugates and secondary bile acid production. Sulfolithocholylglycine is the 3-O-sulfo derivative of glycolithocholic acid and is synthesized through microbial flora enzymes in the colonic environment. In hepatocytes, bile acids, both primary and secondary, undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, resulting in the predominance of glycine-conjugated forms of bile acids in the bile duct. This compound′s unique properties make it an intriguing subject for research, with potential applications in metabolomics and biochemistry.

Application

Sulfoglycolithocholic acid can be used in biochemical research and metabolomics research. It can be used to study the metabolism of bile acids, the gut microbiome, and the effects of bile acids on various tissues and organs.

Features and Benefits

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Takaaki Goto et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 846(1-2), 69-77 (2006-09-05)
We developed a highly sensitive and quantitative method to detect bile acid 3-sulfates in human urine employing liquid chromatography/electrospray ionization-tandem mass spectrometry. This method allows simultaneous analysis of bile acid 3-sulfates, including nonamidated, glycine-, and taurine-conjugated bile acids, cholic acid
Thierry Claudel et al.
Arteriosclerosis, thrombosis, and vascular biology, 25(10), 2020-2030 (2005-07-23)
Bile acids are the end products of cholesterol metabolism. They are synthesized in the liver and secreted via bile into the intestine, where they aid in the absorption of fat-soluble vitamins and dietary fat. Subsequently, bile acids return to the

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