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Key Documents

SAB4300554

Sigma-Aldrich

Anti-NFKB1 (Ab-927) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-DKFZp686C01211 antibody produced in rabbit, Anti-EBP-1 antibody produced in rabbit, Anti-KBF1 antibody produced in rabbit, Anti-MGC54151 antibody produced in rabbit, Anti-nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 antibody produced in rabbit

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About This Item

MDL number:
MFCD00802846
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~120 kDa
 ~50 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(C-D-S-G-V)

NCBI accession no.

NP_001158884.1

UniProt accession no.

P19838

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NFKB1(4790)

General description

NFKB1(nuclear factor κB subunit 1) is a dimeric transcription factor. It belongs to the REL family. It is located on chromosome 4q24.

Immunogen

Peptide sequence around aa. 925-929 (C-D-S-G-V ), according to the protein NFKB1.

Biochem/physiol Actions

NFKB1 (nuclear factor κB subunit 1) controls the maturation of NK (natural killer) cells and effector functions. It helps in the upregulation of intrauterine adhesion inflammatory factors, hence it plays a major role in inflammatory diseases.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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EBV induces persistent NF-?B activation and contributes to survival of EBV-positive neoplastic T- or NK-cells
Takada H, et al.
PLoS ONE, 12(3) (2017)
Yibo Gong et al.
BMC complementary medicine and therapies, 22(1), 224-224 (2022-08-27)
Oxidative stress can induce age-related diseases. Age-related retinal diseases, such as age-related macular degeneration (AMD), are difficult to cure owing to their complicated mechanisms. Although anti-neovascular therapeutics are used to treat wet AMD, vision cannot always be completely restored, and
NFKB1 regulates human NK cell maturation and effector functions
Lougaris V, et al.
Clinical Immunology (Orlando, Fla.), 175, 99-108 (2017)
Elevated NF-?B signaling in Asherman syndrome patients and animal models
Wang X, et al.
Oncotarget, 8(9), 15399-15406 (2017)
J Spring
FEBS letters, 400(1), 2-8 (1997-01-02)
For the growing fraction of human genes with identified functions there are often homologues known from invertebrates such as Drosophila. A survey of well established gene families from aldolases to zinc finger transcription factors reveals that usually a single invertebrate

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