Soluble at 50mg/ml, it can be dissolved in water, but it is recommended to use saline, NaCl, DPBS, Hanks, or culture medium. Please note that a reference in peer- reviewed papers at sial.com isolated glomerular endothelial cells at 0.1% in DMEM. This paper may also be of reference "Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells (https://www.sciencedirect.com/science/article/pii/S0006291X02006939?via%3Dihub)
P5515
Prostaglandin E1
≥98% (HPLC), powder, vasodilator
Synonym(s):
(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1
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1 MG
€207.00
5 MG
€437.00
10 MG
€561.00
About This Item
Empirical Formula (Hill Notation):
C20H34O5
CAS Number:
Molecular Weight:
354.48
Beilstein:
5294062
EC Number:
MDL number:
UNSPSC Code:
12352211
eCl@ss:
42020658
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
Prostaglandin E1, ≥98% (HPLC), synthetic
biological source
synthetic
Quality Level
Assay
≥98% (HPLC)
form
(powder to crystals)
solubility
ethanol: 5 mg/mL
storage temp.
−20°C
SMILES string
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
InChI
1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
InChI key
GMVPRGQOIOIIMI-DWKJAMRDSA-N
Gene Information
human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739)
mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)
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Application
Biochem/physiol Actions
Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase.[4] It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease.[5] It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site.[6] It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO).[7] PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML). [8]
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Annual review of biochemistry, 47, 997-1029 (1978-01-01)
Prostaglandin E1 and its analog misoprostol inhibit human CML stem cell self-renewal via EP4 receptor activation and repression of AP-1
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Cell Stem Cell, 21(3), 359-373 (2017)
Intravenous infusion of prostaglandin E1 therapy in extremity ischemia
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Indian Journal of Vascular and Endovascular Surgery, 4(2), 38-38 (2017)
Articles
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Is stability in solution information available for the product P5515?
Is stability in solution information available for the product P5515?
1 answer-
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What are the recommended storage temperature conditions for Prostaglandin E1 (P5515) when dissolved in acetone?
1 answer-
The solubility test is designed to ensure the product is free of foreign bodies or other unsoluble substances. Acetone was choosen for the solubility test because appears to have higher solubility in acetone than it does in ethanol. The Quality department will dissolve the product in acetone and discard the solution once the solubility test is complete. So there is no data for what is the preferred storage temperature and length of storage if using acetone as the solvent.
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