M2518

Menadione sodium bisulfite

BioReagent, suitable for cell culture, ≥95% (TLC)

• Synonym(s): 2-Methyl-1,4-naphthoquinone sodium bisulfite
• Empirical Formula (Hill Notation): C₁₁H₉NaO₅S
• CAS Number: 130-37-0
• Molecular Weight: 276.24
• EC Number: 204-987-0
• MDL number: MFCD00051456
• UNSPSC Code: 12352205
• PubChem Substance ID: 24896741
• NACRES: NA.75

Properties

• biological source: synthetic (organic)
• product line: BioReagent
• Assay: ≥95% (TLC)
• form: powder
• mol wt: M_w 276.24 g/mol
• technique(s): cell culture | mammalian: suitable; cell culture | plant: suitable
• color: white to off-white
• solubility: water: soluble 50 mg/mL, clear, colorless to light yellow
• storage temp.: −20°C
• SMILES string: [Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
• InChI: 1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
• InChI key: XDPFHGWVCTXHDX-UHFFFAOYSA-M

Description

Application

Menadione sodium bisulfite has been used:

• as a free radical inducer to study its effects on oxidative stress in sunflower seedlings
• as a positive control to produce mitochondrial O₂ during the measurement of O₂ in human proximal tubular cell lines
• as a redox-cycling mitochondrial pro-oxidant to study its effects on protein kinase B (AKT) and mechanistic target of rapamycin (mTOR) signaling in cardiac cells

Biochem/physiol Actions

Menadione sodium bisulfite (MSB) is a derivative of vitamin K3 and has been studied in the treatment of hemorrhagic diseases like hypoprothrombinemia and neonatal hemorrhage, caused due to vitamin K3 deficiency. It is also considered a nutritional supplement for animals. MSB shows anticancer effects. It also protects plants from biotic and abiotic stress.

Other Notes

Water soluble vitamin K₃.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H315,H319,H410
• Precautionary Statements: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves