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M0388

Sigma-Aldrich

6α-Methyl-11β-hydroxyprogesterone

Synonym(s):

11β-Hydroxy-6α-methyl-4-pregnene-3,20-dione, Medrysone

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About This Item

Empirical Formula (Hill Notation):
C22H32O3
CAS Number:
2668-66-8
Molecular Weight:
344.49
EC Number:
220-208-7
MDL number:
MFCD00056477
UNSPSC Code:
12352200
PubChem Substance ID:
24896551
NACRES:
NA.77

sterility

non-sterile

form

solid

shipped in

ambient

storage temp.

2-8°C

SMILES string

[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O

InChI

1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1

InChI key

GZENKSODFLBBHQ-ILSZZQPISA-N

Gene Information

human ... NR3C1(2908)

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Management of vernal conjunctivitis with steroid induced glaucoma--a comparative study.
S Mithal et al.
Indian journal of ophthalmology, 35(5-6), 298-301 (1987-01-01)
N L Verbey et al.
Current eye research, 7(6), 557-561 (1988-06-01)
The effect of topical administration of 3-isobutyl-methyl-xanthine (IBMX), a potent phosphodiesterase inhibitor, was studied on an experimentally provoked uveitis in rabbits. After presensitization with an intravitreal injection of human serum albumin (HSA), intravenous antigenic challenge induces blood-aqueous barrier breakdown and
K Green et al.
Current eye research, 8(3), 317-320 (1989-03-01)
The interaction between a topically administered progesterone, medrysone, and a steroid antagonist, mifepristone, on rabbit intraocular pressure (IOP) has been determined. Medrysone alone increased IOP significantly above parallel controls over the first three weeks; this increase was not sustained. When
Corticosteroids and corneal epithelial wound healing.
G Petroutsos et al.
The British journal of ophthalmology, 66(11), 705-708 (1982-11-01)
J S Mindel et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 98(9), 1577-1578 (1980-09-01)
In age-, race-, and sex-matched groups, the relative abilities of medrysone, fluorometholone, and dexamethasone phosphate to elevate intraocular pressure were compared in a masked manner. Compliance was controlled by drops being given by nursing personnel. The 18 male hospitalized volunteers
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