As mentioned in the Product Datasheet, Lipoteichoic acid is soluble in water (5 mg/ml), yielding
a hazy colorless to faint yellow solution. This document can be located in the 'DOCUMENTATION' section under 'More Documents':
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/175/351/l2515pis.pdf
L2515
Lipoteichoic acid from Staphylococcus aureus
bacterial cell wall polymer
Sign Into View Organizational & Contract Pricing
All Photos(4)
Select a Size
Change View
5 MG
€232.00
10 MG
€431.00
25 MG
€786.25
About This Item
Recommended Products
biological source
Staphylococcus aureus
Quality Level
form
lyophilized powder
functional group
phospholipid
lipid type
polymerizable lipids
shipped in
ambient
storage temp.
2-8°C
Related Categories
General description
Lipoteichoic acid (LTA) is a linear polymer of phosphodiester-linked glycerol phosphate covalently bound to a lipid. The C2 position on the glycerol-phosphate is usually glycosylated or D-alanylated. LTA is amphipathic due to the presence of the negatively charged backbone of glycerol phosphate and the hydrophobic lipid. The lipid portion is bound hydrophobically to the cell membrane, whereas the polyglycerol phosphate portion extends into the cell wall.
Lipoteichoic acid (LTA) is a teichoic acid attached to a lipid abundant on Gram-positive bacteria cell wall. LTA is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.[1]
Application
Lipoteichoic acid from Staphylococcus aureus has been used:
- to investigate the binding properties of SpHyastatin to lipopolysaccharides and lipoteichoic acid using enzyme-linked immunosorbent assay (ELISA)
- to measure the interleukin (IL-6) produced in splenocytes using a sandwich ELISA
- as a toll-like receptor 2/6 (TLR2/6) agonist to explore its potential to induce tumoricidal M1 macrophage phenotype
Biochem/physiol Actions
Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity and functions versus other bacterial LTAs.
Lipoteichoic acid (LTA) is a complex component of the cell walls of Gram-positive bacteria that are implicated in a wide range of cellular processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of Gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity, and functions versus other bacterial LTAs.
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Simin Rezania et al.
Cancer cell international, 14, 54-54 (2014-06-27)
Many types of tumors are organized in a hierarchy of heterogeneous cell populations with different molecular signature. Such heterogeneity may be associated with different responsiveness to microenvironment stimuli. In the present study, the effects of lipopolysaccharide (LPS) and lipoteichoic acid
S Morath et al.
The Journal of experimental medicine, 193(3), 393-397 (2001-02-07)
Lipoteichoic acids (LTAs) have been proposed as putative Gram-positive immunostimulatory counterparts to Gram-negative lipopolysaccharides. However, LTA from Staphylococcus aureus, the clinically most frequent Gram-positive pathogen, was inactive after purification. Here, a novel isolation procedure to prepare pure (>99%) biologically active
Nien-Tzu Chou et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 735396-735396 (2013-01-11)
Chlorella sorokiniana (CS) is a unicellular green alga. The extracts of Chlorella have been used as treatments for relieving hypertension and modulating immune response. The detailed mechanisms are not clear yet. In this study, we sought to study the molecular
Varenka J Barbero-Becerra et al.
World journal of gastroenterology, 17(10), 1317-1325 (2011-04-02)
To study the role of gram-positive and gram-negative bacteria in the pathogenesis of liver injury, specifically the activation of inflammatory mediators. Peripheral blood mononuclear cells of 20 out-patients were studied, 10 of them with cirrhosis. Peripheral blood mononuclear cells were
Gopinath Kasetty et al.
Antimicrobial agents and chemotherapy, 55(6), 2880-2890 (2011-03-16)
Peptides of the C-terminal region of human thrombin are released upon proteolysis and identified in human wounds. In this study, we wanted to investigate minimal determinants, as well as structural features, governing the antimicrobial and immunomodulating activity of this peptide
-
How is it bettere to resuspend the powder? Please add solubility and how to use the product in the "fiche des caractéristique"
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
