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H1396

Sigma-Aldrich

Hexa-N-acetylchitohexaose

≥95%

Synonym(s):

NI, NII, NIII, NIV, NV, NVI-Hexaacetylchitohexaose

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About This Item

Empirical Formula (Hill Notation):
C48H80N6O31
CAS Number:
38854-46-5
Molecular Weight:
1237.17
MDL number:
MFCD00210241
UNSPSC Code:
12352200
PubChem Substance ID:
24895458

Assay

≥95%

storage temp.

−20°C

SMILES string

CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O[C@@H]5O[C@H](CO)[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6NC(C)=O)[C@H](O)[C@H]5NC(C)=O)[C@H](O)[C@H]4NC(C)=O)[C@H](O)[C@H]3NC(C)=O)[C@H](O)[C@H]2NC(C)=O)[C@@H]1O

Substrates

Enhances protection against infection in mice by elevating cellular immunity; exhibits anti-tumor activity against solid tumors; elicits defense systems in plants; and serves as a substrate for human lysozyme.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor.
A Tokoro et al.
Chemical & pharmaceutical bulletin, 36(2), 784-790 (1988-02-01)
K Tsukada et al.
Japanese journal of cancer research : Gann, 81(3), 259-265 (1990-03-01)
N-Acetylchitohexaose, a water-soluble oligosaccharide was found to display a significant antimetastatic effect against Lewis lung carcinoma (LLC) transplanted into C57BL/6 mice, giving rise to a 40-50% inhibition ratio of pulmonary metastasis when administered intravenously (1 mg/kg) on day 6 after
T Usui et al.
Carbohydrate research, 203(1), 65-77 (1990-08-01)
A chitinase purified from culture filtrates of Trichoderma resei KDR-11 efficiently catalyzed a transglycosylation reaction on tetra-N-acetylchitotetraoside in a buffer medium containing ammonium sulfate, converting the tetrasaccharide into hexa-N-acetylchitohexaose (39.6%) and di-N-acetylchitobiose (55.7%) as the major products. Sugar-chain elongation from
M Muraki et al.
Biochemistry, 35(42), 13562-13567 (1996-10-22)
In order to reveal the origin of carbohydrate recognition specificity of human lysozyme by clarifying the difference in the binding mode of ligands in the active site, the inactivation of human lysozyme by 2',3'-epoxypropyl beta-glycoside derivatives of the disaccharides, N,N'-diacetylchitobiose
M Kobayashi et al.
Microbiology and immunology, 34(5), 413-426 (1990-01-01)
A water-soluble oligosaccharide, N-acetylchitohexaose (NACOS-6), was able to enhance the protective effect against Candida albicans infection in mice during the early phase of tumor-bearing. A significant decrease in the number of C. albicans cells in the kidneys of NACOS-6-treated tumor-bearing
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