DNA ligase I is composed of a 78kDa carboxyl-terminal catalytic domain and a 24kDa amino-terminal region.
Immunogen
bovine DNA ligase I.
Application
Monoclonal Anti-DNA Ligase I antibody produced in mouse is suitable for direct ELISA and western blot at a working concentration of 1-5μg/mL using HeLa or DiFi cells.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Journal of biological chemistry, 272(17), 11550-11556 (1997-04-25)
The joining of Okazaki fragments during lagging strand DNA replication in mammalian cells is believed to be due to DNA ligase I. This enzyme is composed of a 78-kDa carboxyl-terminal catalytic domain and a 24-kDa amino-terminal region that is not
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.