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C1244

Sigma-Aldrich

CHM-1 hydrate

≥99% (HPLC), solid

Synonym(s):

2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158

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About This Item

Empirical Formula (Hill Notation):
C16H10FNO3 · xH2O
CAS Number:
154554-41-3
Molecular Weight:
283.25 (anhydrous basis)
MDL number:
MFCD11114577
UNSPSC Code:
12352202
PubChem Substance ID:
329774746
NACRES:
NA.77

Assay

≥99% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

O.Fc1ccccc1C2=CC(=O)c3cc4OCOc4cc3N2

InChI

1S/C16H10FNO3.H2O/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12;/h1-7H,8H2,(H,18,19);1H2

InChI key

KIAVGSCBJYDTIM-UHFFFAOYSA-N

Biochem/physiol Actions

CHM-1 possess antimitotic and antiangiogenic antitumor activity.
CHM-1 possess antimitotic,antiangiogenic and antitumor activity. It is a potent and selective antitumor agent in human hepatocellular carcinoma. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
058K4602V
058K4602

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