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B7775

Sigma-Aldrich

[Hyp3]-Bradykinin

≥97% (HPLC), suitable for cell culture

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About This Item

Empirical Formula (Hill Notation):
C50H73N15O12
CAS Number:
37642-65-2
Molecular Weight:
1076.21
MDL number:
MFCD00076259
UNSPSC Code:
12352200
PubChem Substance ID:
329773302
Pricing and availability is not currently available.

Product Name

[Hyp3]-Bradykinin, ≥97% (HPLC)

Assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

UniProt accession no.

P06767

storage temp.

−20°C

SMILES string

N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C50H73N15O12/c51-32(15-7-19-56-49(52)53)45(73)64-22-10-18-38(64)47(75)65-27-31(67)25-39(65)43(71)58-26-40(68)59-34(23-29-11-3-1-4-12-29)41(69)62-36(28-66)46(74)63-21-9-17-37(63)44(72)61-35(24-30-13-5-2-6-14-30)42(70)60-33(48(76)77)16-8-20-57-50(54)55/h1-6,11-14,31-39,66-67H,7-10,15-28,51H2,(H,58,71)(H,59,68)(H,60,70)(H,61,72)(H,62,69)(H,76,77)(H4,52,53,56)(H4,54,55,57)/t31-,32+,33+,34+,35+,36+,37+,38+,39+/m1/s1

InChI key

JXRLHZCEMXTCBN-DIBGMJQNSA-N

Gene Information

rat ... Tac1(24806)

Amino Acid Sequence

Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg

Biochem/physiol Actions

[Hyp3]-Bradykinin is a bradykinin receptor agonist used to differentiate bradykinin receptors in various cells, tissues and species.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
051M1680V
051M1680
060M1517
099K1571
069K1200

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[Structures and functions of kininogen and kinin hydroxyproline derivatives as multi-functional proteins].
H Kato
[Rinsho ketsueki] The Japanese journal of clinical hematology, 30(10), 1690-1693 (1989-10-01)
R Dengler et al.
FEBS letters, 262(1), 111-114 (1990-03-12)
The recently isolated, naturally occurring peptide hormones [Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin were investigated for their agonist activity on solubilized binding sites from human fibroblasts. Both ligands competed with [3H]bradykinin binding in a dose-dependent fashion with potencies similar to bradykinin (BK) and
D Regoli et al.
Life sciences, 55(10), 735-749 (1994-01-01)
Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characterization was made in the rabbit jugular vein and the guinea pig ileum, two widely
M Sasaguri et al.
Biochemical and biophysical research communications, 157(1), 210-217 (1988-11-30)
Aside from bradykinin (BK), a novel kinin, [Hydroxyproline3]-bradykinin ( [Hyp3]-BK), was isolated from the reaction mixture of human plasma and plasma protein Cohn's fraction IV-4 with trypsin. The liberated kinins were isolated based on procedures which we previously described for
H Kato et al.
Agents and actions. Supplements, 38 ( Pt 1), 217-224 (1992-01-01)
Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible sites for hydroxylation of
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