B0189

Casticin

from Vitex trifolia, ≥98% (HPLC)

• Synonym(s): Casticine, Quercetagetin 3,6,7,4′-tetramethyl ether, Vitexicarpin
• Empirical Formula (Hill Notation): C₁₉H₁₈O₈
• CAS Number: 479-91-4
• Molecular Weight: 374.34
• UNSPSC Code: 12352200
• NACRES: NA.25

Properties

• biological source: Vitex trifolia
• Assay: ≥98% (HPLC)
• form: powder
• solubility: ethanol: 1 mg/mL, clear, colorless to light yellow
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• InChI: 1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
• InChI key: PJQLSMYMOKWUJG-UHFFFAOYSA-N

Description

General description

Casticin is one of the flavonoids present in the traditional Chinese medicine Inula japonica Thunb. It is a polymethyl compound with three rings, a catechol moiety at ortho position, one double bond, two hydroxyl groups, and four methoxy groups. It has been isolated from the fruits, seeds, and leaves of various Vitex species.

Application

Casticin from Vitex trifolia is used to study its mechanisms of action as an antiiflammatory and anticancer agent via processes such as TRAIL-induced apoptosis, cell cycle arrest, ROS generation, and glutathione (GSH) depletion.

Biochem/physiol Actions

Casticin has anticancer, pro-apoptotic, anti-proliferative, anti-asthmatic, and anti-angiogenic properties. In addition, it exhibits anti-inflammatory behavior by means of its inhibitory effect on lipoxygenases and T- & B-lymphocytes. Due to its oestrogenic activity, it is being used to manage Premenstrual syndrome in women. It is also reported to mitigate rheumatoid arthritis and liver fibrosis manifestations.

Tubulin-binding anticancer flavonoid. Casticin induces apoptosis in cancer cells.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable