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D0501

Supelco

4-Deoxypyridoxine hydrochloride

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C8H11NO2 · HCl
CAS Number:
148-51-6
Molecular Weight:
189.64
EC Number:
205-714-8
MDL number:
MFCD00051296
UNSPSC Code:
41116107
PubChem Substance ID:
329798615
NACRES:
NA.24

biological source

synthetic (organic)

Quality Level

100

grade

analytical standard

Assay

≥98%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white to yellow

mp

263-265 °C

application(s)

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

format

neat

storage temp.

−20°C

SMILES string

Cl.Cc1ncc(CO)c(C)c1O

InChI

1S/C8H11NO2.ClH/c1-5-7(4-10)3-9-6(2)8(5)11;/h3,10-11H,4H2,1-2H3;1H

InChI key

QZKKOQQIVLXUEI-UHFFFAOYSA-N

General description

4-Deoxypyridoxine hydrochloride is a strong antagonist of vitamin B6.

Application

4-Deoxypyridoxine hydrochloride analytical standard can be used as follows:
  • Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with mass spectrometric (MS) detection for the impurity analysis of metadoxine drug
  • As an internal standard in the ultra- and high- performance liquid chromatographic analysis of pyridoxine in multivitamin tablet samples coupled with UV, mass spectrometric, and fluorescence detector

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000340997
0000340997
WXBF2787V
WXBF3938V
0000245414

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A Trakatellis et al.
Postgraduate medical journal, 68 Suppl 1, S70-S77 (1992-01-01)
Measurements of serine hydroxymethyltransferase (SHMT) in resting lymphocyte cultures showed that the level of activity of this enzyme was very low. Under the influence of mitogenic stimuli serine hydroxymethyl-transferase activity was induced 5-20-fold. Addition in the cultures of 4-deoxypyridoxine, a
J Scountzou et al.
Immunopharmacology and immunotoxicology, 11(4), 657-666 (1989-01-01)
We studied the effect of pyridoxine deficiency state on the responses of human lymphocytes to certain mitogenic factors. Deoxypyridoxine (DB6), a potent pyridoxine antagonist, considerably inhibited Bromodeoxyuridine (BrdU) incorporation into the newly synthesized DNA of lymphocytes cultured with Phytohemagglutinin (PHA)
HPLC analysis of vitamin B6 in foods
Ollilainen, V-M
Agricultural and food science, 8(6), 515-619 (1999)
T Yagi et al.
Biochimie, 71(4), 427-438 (1989-04-01)
The intracellular proportion of the pyridoxal 5'-phosphate form of aspartate aminotransferase to the total enzyme in E. coli B cells was determined by a newly devised method, dependent on selective inactivation of the intracellular pyridoxal 5'-phosphate form of the enzyme
W F Wolkers et al.
The Journal of biological chemistry, 266(31), 20761-20766 (1991-11-05)
The distances between enzyme-bound paramagnetic CrATP (a stable, beta, gamma-bidentate complex of Cr3+ and ATP) at the active site of sheep brain pyridoxal kinase and the protons of bound inhibitor 4-dPyr (4-deoxypyridoxine) were determined in the ternary enzyme-CrATP.4-dPyr complex by
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