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C2174000

Cilazapril

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Cilazapril monohydrate

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About This Item

Empirical Formula (Hill Notation):
C22H31N3O5 · H2O
CAS Number:
92077-78-6
Molecular Weight:
435.51
MDL number:
MFCD01692810
UNSPSC Code:
41116107
NACRES:
NA.24
Pricing and availability is not currently available.

grade

pharmaceutical primary standard

API family

cilazapril

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N21N(CCC[C@H]2C(=O)O)CCC[C@@H](C1=O)N[C@@H](CCc3ccccc3)C(=O)OCC.O

InChI

1S/C22H31N3O5.H2O/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26;/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28);1H2/t17-,18-,19-;/m0./s1

InChI key

JQRZBPFGBRIWSN-YOTVLOEGSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cilazapril EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

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Spironolactone attenuates oxidative stress in patients with chronic kidney disease.
Marcin Renke et al.
Hypertension (Dallas, Tex. : 1979), 52(5), e132-e133 (2008-10-01)
Milan R Radovanović et al.
Vojnosanitetski pregled, 66(11), 904-908 (2009-12-19)
Poisoning caused by drugs with cardiodepressive effects is an urgent condition in medicine which is associated with high mortality rate regardless of modern therapeutic methods. Accidental or intentional poisoning whit these drugs produces heart activity depression and cardiovascular collapse as
Izzet Hosgor et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 19(1), 101-105 (2008-01-09)
Impaired fibrinolysis is associated with thromboembolic complications in hypertensive patients. Cardiovascular morbidity/mortality rates have been reported high even after lowering the elevated blood pressure with antihypertensive drugs. We investigated the effects of clinically used dosages of cilazapril on the fibrinolytic
Nikola Radović et al.
Croatian medical journal, 49(5), 600-607 (2008-10-18)
To investigate the effects of angiotensin-converting enzyme inhibitor (cilazapril) and angiotensin II type I receptor antagonist (losartan) on tubular and interstitial cell apoptosis and caspase-3 activity in rats with obstructive nephropathy after unilateral ureteral obstruction. Rats with unilateral obstructive nephropathy
Shih-Hsien Sung et al.
Journal of the Chinese Medical Association : JCMA, 71(5), 247-253 (2008-05-21)
Combined regimen may be superior to monotherapy in blood pressure (BP) control. Since BP control is critically related to cardiovascular mortality and morbidity in hypertensive patients, this study aimed to evaluate the efficacy and safety of a low-dose combined regimen
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