Galanin is a neuropeptide which is not a member of any known family of neuropeptides, despite repeated efforts to discover related peptides. Its actions are mediated via Gi-protein-coupled receptors (GPCR’s) and ion channels, usually producing inhibition of secretion of a transmitter or hormone in the nervous and endocrine system. In many respects, these inhibitory actions of galanin remind us of those of gamma-aminobutyric acid (GABA) and of neuropeptide Y (NPY). Galanin coexists with GABA, noradrenaline, 5-hydroxytryptamine (5-HT), and NPY in several regions of the brain. Galanin and it’s receptor are over expressed in limbic region of the brain in patients suffering from Alzheimer′s disease. However it is not clear whether galanin exacerbates or is a protective response to the disease.
Specificity
Cat. # AB2233 recognizes Galanin
Reactivity with other species has not been determined.
Immunogen
Synthetic Linear Peptide
Application
Detect Galanin using this Anti-Galanin Antibody validated for use in IH(P).
Research Category Neuroscience
Research Sub Category Neurochemistry & Neurotrophins
Quality
Routinely evaluated by Immunhistochemistry on rat cerebellum tissue.
Target description
13.3 kDa
Physical form
Serum with 0.05% NaN3
Storage and Stability
Maintain at -20°C for up to 1 year from date of receipt.
Analysis Note
Control Rat Cerebellum Tissue
Disclaimer
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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