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Sigma-Aldrich

Fmoc-Lys(Me)₂-OH HCl

≥95.0% (HPLC), for peptide synthesis, Novabiochem®

Synonym(s):

Fmoc-Lys(Me)₂-OH HCl, N-α-Fmoc-N-ε-dimethyl-N-L-lysine · hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H28N2O4 · xHCl
CAS Number:
252049-10-8
Molecular Weight:
396.48 (free base basis)
UNSPSC Code:
12352209
NACRES:
NA.22

product name

Fmoc-Lys(Me)₂-OH HCl, Novabiochem®

Quality Level

200

product line

Novabiochem®

Assay

≥95% (TLC)
≥95.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

-10 to -25°C

InChI

1S/C23H28N2O4.ClH/c1-25(2)14-8-7-13-21(22(26)27)24-23(28)29-15-20-18-11-5-3-9-16(18)17-10-4-6-12-19(17)20;/h3-6,9-12,20-21H,7-8,13-15H2,1-2H3,(H,24,28)(H,26,27);1H/t21-;/m0./s1

InChI key

SJFAFKDBWNFBCC-BOXHHOBZSA-N

General description

A novel derivative for the introduction of dimethyl-lysine during Fmoc SPPS. Ref [1] contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.


Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

[1] S. Rothbart, et al. (2012) Methods Enzymol., 512, 107.

Linkage

Replaces: 04-12-1269

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA1)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Acetate (IC): ≤ 1.0 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Unnatural Amino Acids for Peptide Synthesis

Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.

Protocols

Building Blocks for Introducing Post-translational Modified Amino Acids

We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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