10926

9-Fluorenylmethyl N-hydroxycarbamate

≥99.0%

• Synonym(s): N-(9-Fluorenylmethoxycarbonyl)hydroxylamine, N-Fmoc-hydroxylamine
• Empirical Formula (Hill Notation): C₁₅H₁₃NO₃
• CAS Number: 190656-01-0
• Molecular Weight: 255.27
• Beilstein: 7712144
• MDL number: MFCD01862911
• UNSPSC Code: 12352005
• PubChem Substance ID: 57646856

Properties

• Assay: ≥99.0%
• mp: 164.5 °C (lit.)
• application(s): peptide synthesis
• SMILES string: ONC(=O)OCC1c2ccccc2-c3ccccc13
• InChI: 1S/C15H13NO3/c17-15(16-18)19-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14,18H,9H2,(H,16,17)
• InChI key: HHNJBGORPSTJDX-UHFFFAOYSA-N

Description

Application

9-Fluorenylmethyl N-hydroxycarbamate (Fmoc-NHOH) can be used as a reactant to prepare:

• N-Fmoc-aminooxy-2-chlorotrityl polystyrene, a solid-phase resin used to produce hydroxamic acids and peptidyl hydroxamic acids.
• 9-Fluorenylmethyl nosyloxycarbamate (Fmoc-NHONs) by reacting with nosyl chloride.

Other Notes

Building block for the solid-phase synthesis of (peptide) hydroxamic acids on chlorotrityl resin

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves