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Merck

AR

androgen receptor

Synonyms:
AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Species:
Human AR (367), Mouse Ar (11835), Rat Ar (24208), fruit fly ar (44503), Zebrafish ar (100005148), chicken AR (422165), dog AR (403588), domestic cat AR (101081787), domestic cat AR (751827), Horse AR (100033980) ...More
UniProtKB ID:
P10275, A2RUN2, B1AKD7, Q9UD95
Gene ID:
  • Human(367) Summary: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(11835) androgen receptor
  • Rat(24208) androgen receptor
  • fruit fly(44503) abdomen rotatum
  • Zebrafish(100005148) androgen receptor
  • chicken(422165) androgen receptor
  • dog(403588) androgen receptor
  • domestic cat(101081787) androgen receptor
  • domestic cat(751827) androgen receptor
  • Horse(100033980) androgen receptor
  • cow(280675) androgen receptor
  • sheep(443042) androgen receptor
  • Goat(100860827) androgen receptor
  • Domestic Rabbit(100009193) androgen receptor
  • domestic guinea pig(100726891) androgen receptor

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Activator

Product Number
Description
Species
N4128
19-Norethindrone, ≥98%, powder,
Species
human, rat
E8750
α-Estradiol, powder, ≥98% (TLC),
Species
human, rat
484431
Propylene glycol monomethyl ether acetate, ReagentPlus®, ≥99.5%,
Species
human
D4628
Diethylstilbestrol, ≥99% (HPLC),
Species
human, mouse, rat
R5010
Resveratrol, ≥99% (HPLC),
Species
human, rat, mouse

Small Molecule - Agonist

Product Number
Description
Species
46444
17α-Methyltestosterone, VETRANAL®, analytical standard,
Species
human
Y0001409
Testosterone propionate for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
M1800000
Methyltestosterone, European Pharmacopoeia (EP) Reference Standard,
Species
human
1455000
Nandrolone decanoate, United States Pharmacopeia (USP) Reference Standard,
Species
human
1648004
Testosterone enanthate, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
C55208
4-Chloro-2-methylphenol, 97%,
Species
rat
I17206
Isoeugenol, 98%, mixture of cis and trans,
Species
rat
430676
2,2,5,7,8-Pentamethyl-6-chromanol, 97%,
Species
human
W246808
Isoeugenol, mixture of cis and trans, 99%, FG,
Species
rat
372102
4-Dodecylphenol, mixture of isomers, ,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
SAB1306176
ANTI-ANDROGEN RECEPTOR (ANDR) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
SAB4301320
Anti-phospho-Androgen Receptor (pTyr363) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
western blot
SAB5500007
Anti-Androgen Receptor (C-term) antibody, Rabbit monoclonal, clone SP242, recombinant, expressed in proprietary host, affinity isolated antibody,
Species Reactivity
dog, human, mouse, pig, rabbit, rat
Application
immunohistochemistry
SAB2100139
Anti-AR antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, horse, human, pig
Application
western blot
SAB4501575
Anti-Androgen Receptor antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot

Small Molecule - Blocker

Product Number
Description
Species
F9397
Flutamide, ,
Species
mouse, rat, human

Small Molecule - Inhibitor

Product Number
Description
Species
SML1375
Galeterone, ≥98% (HPLC),
Species
human
158348
4-(Benzyloxy)phenol, 98%,
Species
rat, human
136123
trans-Chalcone, 97%,
Species
rat, human
86541
Testosterone propionate, tested according to Ph. Eur.,
Species
human, rat
S3378
Spironolactone, 97.0-103.0%,
Species
rat, human

Small Molecule - Ligand

Product Number
Description
Species
86500
Testosterone, purum, ≥99.0% (HPLC),
Species
human
46923
Testosterone, VETRANAL®, analytical standard,
Species
human
H4637
4-Hydroxyestradiol, ,
Species
rat, human
T5648
Tamoxifen, ≥99%,
Species
human, rat
T1500
Testosterone, ≥98%,
Species
mouse, human, rat

Proteins

Product Number
Description
Species
SRP2071
Androgen receptor (650-920), human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
346101-M
Androgen Receptor, His•Tag®, Human, Recombinant, S. frugiperda, recombinant human, expressed in S. frugiperda,
Species
human

esiRNA

Product Number
Description
Species
EMU006201
MISSION® esiRNA, targeting mouse Ar,
Species
mouse
EHU025951
MISSION® esiRNA, targeting human AR,
Species
human