Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)

Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw

PMID22099160

ZUSAMMENFASSUNG

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

11009

Sigma-Aldrich

Aluminium, powder, ≥91% (complexometric)

266558

Sigma-Aldrich

Aluminium, wire, diam. 1.0 mm, 99.999% trace metals basis

518573

Sigma-Aldrich

Aluminium, granular, <1 mm, 99.7% trace metals basis

326852

Sigma-Aldrich

Aluminium, foil, thickness 0.25 mm, 99.999% trace metals basis

266523

Sigma-Aldrich

Aluminium, ReagentPlus^®, beads, 5-15 mm, 99.9% trace metals basis

338788

Sigma-Aldrich

Aluminium, pellets, 3-12 mm, 99.99% trace metals basis

266574

Sigma-Aldrich

Aluminium, foil, thickness 0.45-0.55 mm, 99.999% trace metals basis

310360

Sigma-Aldrich

Aluminium, ACS reagent, 99%, wire, wire diam. ~1.5 mm

326860

Sigma-Aldrich

Aluminium, foil, thickness 0.13 mm, ≥99.99% trace metals basis

326887

Sigma-Aldrich

Aluminium, wire, diam. 0.58 mm, ≥99.99% trace metals basis

733369

Sigma-Aldrich

Aluminium, foil, thickness 8 μm, 99% trace metals basis

GF44675781

Aluminium, rod, 1000mm, diameter 12.7mm, 99%

266957

Sigma-Aldrich

Aluminium, foil, thickness 1.0 mm, 99.999% trace metals basis

326941

Sigma-Aldrich

Aluminium, pellets, 3-8 mesh, ≥99.999% trace metals basis

GF98718935

Aluminium, sphere, 100pcs, diameter 1.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

433705

Sigma-Aldrich

Aluminium, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

GF24569602

Aluminium, foam, 150x150mm, thickness 30mm, bulk density 0.2g/cm³, porosity 0.93, aluminum 6101 grade, 98.5%

GF26812043

Aluminium, foam, 150x150mm, thickness 3.2mm, bulk density 0.2g/cm³, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%

GF94706354

Aluminium, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF51598761

Aluminium, rod, 200mm, diameter 12.7mm, 99%

GF29732496

Aluminium, tube, 200mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%

GF32029444

Aluminium, rod, 100mm, diameter 12.7mm, 99%

GF64700524

Aluminium, rod, 1000mm, diameter 5.0mm, as drawn, 99.999%

GF51278070

Aluminium, honeycomb, 300x300mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm³, phenolic adhesive (resin), 99.5%

GF95825403

Aluminium, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF12712610

Aluminium, sphere, 100pcs, diameter 6.0mm, 99%

GF63629219

Aluminium, tube, 500mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

IRMM523B

Aluminium, IRMM^®, certified reference material, 1.0 mm foil

GF32182534

Aluminium, wire reel, 10m, diameter 0.25mm, as drawn, 99.95+%

GF72634103

Aluminium, rod, 50mm, diameter 28mm, as drawn, 99.999%