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Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.

Bioorganic & medicinal chemistry letters (2009-05-12)
Bianca Sperl, Markus H J Seifert, Thorsten Berg
ZUSAMMENFASSUNG

In this Letter, we report the natural products salvianolic acid A, salvianolic acid B, and caftaric acid as inhibitors of the protein-protein interactions mediated by the SH2 domains of the Src-family kinases Src and Lck, two established disease targets. Moreover, we propose a binding mode for the inhibitors based on molecular modeling, which will facilitate chemical optimization efforts of these important lead structures for drug discovery.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Chlorogensäure, ≥95% (titration)
Sigma-Aldrich
Rosmarinsäure, 96%
Chlorogensäure, primary reference standard