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Z4402

Sigma-Aldrich

Zinterol hydrochloride

≥98% (HPLC)

Synonym(e):

Zinterol hydrochloride, N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-Methanesulfonamide Hydrochloride; MJ 9184

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About This Item

Empirische Formel (Hill-System):
C19H26N2O4S·HCl
CAS-Nummer:
38241-28-0
Molekulargewicht:
414.95
MDL-Nummer:
MFCD00867031
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329831614
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Löslichkeit

DMSO: ≥15 mg/mL

Lagertemp.

room temp

SMILES String

CC(C)(Cc1ccccc1)NCC(O)c2ccc(O)c(NS(C)(=O)=O)c2

InChI

1S/C19H26N2O4S/c1-19(2,12-14-7-5-4-6-8-14)20-13-18(23)15-9-10-17(22)16(11-15)21-26(3,24)25/h4-11,18,20-23H,12-13H2,1-3H3

InChIKey

XJBCFFLVLOPYBV-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Zinterol Hydrochloride is a β2 adrenergic receptor selective agonist.

Leistungsmerkmale und Vorteile

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319

Gefahreneinstufungen

Eye Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Ismayil Ahmet et al.
Circulation, 110(9), 1083-1090 (2004-08-18)
Studies in isolated cardiac myocytes have demonstrated that signaling via specific beta1-adrenergic receptor subtypes (beta1ARs) promotes but that signaling via beta2ARs protects from cell death. We hypothesized that prolonged beta(2)AR stimulation or beta1AR blockade would each protect myocytes from death
George E Billman et al.
American journal of physiology. Heart and circulatory physiology, 290(6), H2590-H2599 (2006-01-03)
Enhanced cardiac beta(2)-adrenoceptor (beta(2)-AR) responsiveness can increase susceptibility to ventricular fibrillation (VF). Exercise training can decrease cardiac sympathetic activity and could, thereby, reduce beta(2)-AR responsiveness and decrease the risk for VF. Therefore, dogs with healed myocardial infarctions were subjected to
Susan F Steinberg et al.
American journal of physiology. Heart and circulatory physiology, 282(4), H1181-H1188 (2002-03-15)
We studied the role of beta-adrenergic receptor subtype signaling to cAMP and calcium in the genesis of catecholamine-dependent arrhythmias in German shepherd dogs that develop lethal arrhythmias at ~5 mo of age. There were three major findings in this study:
H E Lara et al.
Endocrine, 15(2), 187-192 (2001-11-27)
We investigated the possibility that norepinephrine from the human ovary is released after nerve stimulation and that this neurotransmitter is coupled to a steroidogenic response. Biologically significant levels of both norepinephrine and dopamine were found in human ovarian biopsies. [3H]norepinephrine
S Magne et al.
The Journal of biological chemistry, 276(43), 39539-39548 (2001-08-17)
We have recently reported that arachidonic acid mediates beta(2)-adrenergic receptor (AR) stimulation of [Ca(2+)](i) cycling and cell contraction in embryonic chick ventricular cardiomyocytes (Pavoine, C., Magne, S., Sauvadet, A., and Pecker, F. (1999) J. Biol. Chem. 274, 628-637). In the
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Artikel

β-Adrenoceptors

β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.

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