WH0006741M1

Monoclonal Anti-SSB antibody produced in mouse

clone 1D6-H5, purified immunoglobulin, buffered aqueous solution

• Synonym(e): Anti-Sjogren syndrome antigen B (autoantigen La)
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 1D6-H5, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• Isotyp: IgG1κ
• GenBank-Hinterlegungsnummer: BC001289
• UniProt-Hinterlegungsnummer: P05455
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SSB(6741)

Beschreibung

Allgemeine Beschreibung

The Sjogren syndrome antigen B (SSB) gene with 11 exons contains two alternative promoters 1 (P1) and 1′ (P1′) coding for SSB protein. The gene is mapped to human chromosome 2q31.1. The gene coded for a RNA-binding protein that is ubiquitously expressed.

Immunogen

SSB (AAH01289, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

Biochem./physiol. Wirkung

Sjogren syndrome antigen B (SSB) plays a vital role in various stages of the RNA metabolism such as RNA polymerase III protection from exonuclease digestion, processing of specific cellular and viral RNA precursors, serving as an RNA chaperone, affecting telomere homeostasis and stimulating microRNA expression. It promotes proliferation, migration and invasion of cancer cells in vitro . In addition, it also enhances tumor growth in vivo. Overexpression of the gene has been observed in various types of cancers.

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Rechtliche Hinweise

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Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)