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T7540

Sigma-Aldrich

Tyrphostin 47

≥98%

Synonym(e):

α-Cyan-3,4-dihydroxy-thiocinnamamid, RG 50864

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About This Item

Empirische Formel (Hill-System):
C10H8N2O2S
CAS-Nummer:
118409-60-2
Molekulargewicht:
220.25
Beilstein:
6508337
MDL-Nummer:
MFCD00133902
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278755

Assay

≥98%

Wirksamkeit

2.4 μM IC50

Löslichkeit

DMSO: soluble 50 mg/mL, clear, orange
ethanol: soluble

Lagertemp.

2-8°C

SMILES String

NC(=S)\C(=C\c1ccc(O)c(O)c1)C#N

Angaben zum Gen

human ... CDK2(1017) , EGFR(1956)

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Anwendung

Tyrphostin 47 has been used in LOPAC screening assays to identify human tissue transglutaminase (TGM2) inhibitors. Tyrphostin 47 has also been used to study its effects on hyperpolarization-activated cation current in porcine pacemaker cells.

Biochem./physiol. Wirkung

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
EGFR Tyrosin-Kinase-Inhibitor

Angaben zur Herstellung

Tyrphostin 47 is is soluble in DMSO (50 mg/ml) and yields a clear, orange solution. The product is also soluble in ethanol (40 mM).

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Maribel Diaz-Ricart et al.
Thrombosis research, 121(6), 873-883 (2007-10-02)
Platelet activation leads to signal transduction mechanisms, in which phosphotyrosine proteins play a relevant role. Platelet suspensions were independently activated by collagen and thrombin in the absence and in the presence of two tyrosine kinase inhibitors, tyrphostin 47 and genistein.
Naoki Kimura et al.
Bioconjugate chemistry, 18(6), 1778-1785 (2007-10-24)
The present study reported proof-of-principle for a kinase assay approach that can detect specific peptide phosphorylation events. The method involves attachment of peptides onto commercial aminosilane and polycarbodiimide-coated glass slides, using a newly developed DNattach linker system that consists of
Yorimasa Ogata et al.
Cell biology international, 27(8), 689-693 (2003-07-18)
Bradykinin (1 microM) and histamine (100 microM) evoked an initial transient increase and a subsequent sustained increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fura-2-loaded human gingival fibroblasts, which may be attributed to Ca(2+) release from intracellular stores and Ca(2+) entry
Jun Takeda et al.
Development, growth & differentiation, 44(6), 501-508 (2002-12-21)
During the development of the chicken proventriculus (glandular stomach), the initially undifferentiated epithelium differentiates into two distinct cell populations: the glandular epithelium, cells of which secrete embryonic chicken pepsinogen (ECPg), and luminal epithelial cells, which express the chicken spasmolytic polypeptide
S Shibata et al.
British journal of pharmacology, 128(6), 1284-1290 (1999-12-01)
1 The hyperpolarization-activated cation current (If) was recorded in single pacemaker cells of the porcine sino-atrial node, and the effects of genistein, an isoflavone inhibitor of tyrosine-specific protein kinases was investigated by the whole-cell patch clamp technique. 2 Genistein (20-500
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