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T113

Sigma-Aldrich

3-Tropanylindole-3-carboxylate methiodide

solid

Synonym(e):

ICS-205,930 methiodide

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About This Item

Empirische Formel (Hill-System):
C18H23IN2O2
CAS-Nummer:
115626-53-4
Molekulargewicht:
426.29
MDL-Nummer:
MFCD00210222
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278764

Form

solid

Farbe

white

Löslichkeit

H2O: soluble
ethanol: soluble

Lagertemp.

−20°C

SMILES String

[I-].C[N+]1(C)C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34

Angaben zum Gen

human ... HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)

Anwendung

3-Tropanylindole-3-carboxylate methiodide was used to study the role of 5-HT3 receptor-mediated cell signaling in mouse interstitial cells of Cajal and in cocaine-induced aggressive behavior in hamsters.

Biochem./physiol. Wirkung

3-Tropanylindole-3-carboxylate methiodide is an antagonist of 5-HT3 receptor that has antiemetic effects. It modulates the pacemaker activities of the mouse small intestine cells. It regulates the aggressive behavior induced by cocaine in hamsters.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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[3H]quaternised ICS 205-930 labels 5-HT3 receptor binding sites in rat brain.
K J Watling et al.
European journal of pharmacology, 149(3), 397-398 (1988-05-10)
Pawan Kumar Shahi et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 15(3), 129-135 (2011-08-24)
In this study we determined whether or not 5-hydroxytryptamine (5-HT) has an effect on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine. The actions of 5-HT on pacemaker activities were investigated using a whole-cell
K J Watling et al.
European journal of pharmacology, 182(3), 465-472 (1990-07-17)
Clozapine, an atypical neuroleptic drug devoid of extrapyramidal side effects, was a moderately potent, competitive inhibitor of the binding of [3H]quaternised ICS 205-930 to 5-HT3 receptor sites in rat cortical membranes, possessing a pKi value of 7.0. In contrast, several
Lesley A Ricci et al.
Behavioural brain research, 156(1), 19-29 (2004-10-12)
Hamsters repeatedly exposed to cocaine during adolescence display high levels of offensive aggression compared to saline-treated littermates. The escalated offensive phenotype observed in adolescent cocaine-treated animals is modulated by serotonin (5-HT) signaling and can be suppressed by inhibiting 5-HT type

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