SRP5269

HDAC7, active, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): DKFZp586J0917, FLJ99588, HD7A, HDAC7A
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Rekombinant: expressed in baculovirus infected Sf9 cells
• Assay: ≥70% (SDS-PAGE)
• Form: buffered aqueous glycerol solution
• Spezifische Aktivität: 64-96 RLU/min·ng
• Mol-Gew.: ~80 kDa
• NCBI-Hinterlegungsnummer: NM_015401
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... HDAC7(51564)

Beschreibung

Allgemeine Beschreibung

HDAC7 or Histone deacetylase 7 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. The protein encoded by HDAC7 gene has sequence homology to members of the histone deacetylase family whose protein promotes repression mediated via the transcriptional co-repressor SMRT. HDAC7 interacts with β-catenin keeping endothelial cells in a low proliferation stage. HDAC7 regulates NUR77 and apoptosis in developing thymocytes. HDAC7 is expressed in human osteoarthritis that contributes to cartilage degradation via promoting MMP-13 gene expression.

Physikalische Form

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Angaben zur Herstellung

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable