SRP5213

PHLPP2 (766-1043), GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): KIAA0931, PHLPPL
• CAS-Nummer: 1190937-02-0
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: ≥70% (SDS-PAGE)
• Form: buffered aqueous glycerol solution
• Mol-Gew.: ~56 kDa
• NCBI-Hinterlegungsnummer: NM_015020
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... PHLPP2(23035)

Beschreibung

Allgemeine Beschreibung

PHLPP2 or PH domain and leucine rich repeat protein phosphatase 2 is the important regulators of Akt serine-threonine kinases and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 differentially regulated AKT signaling by selectively dephosphorylating the hydrophobic motifs of AKT2 or AKT3. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to block growth factor-induced signaling in cancer cells.

Physikalische Form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Angaben zur Herstellung

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1