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SML2779

Sigma-Aldrich

Tanaproget

≥98% (HPLC)

Synonym(e):

5-(1,4-Dihydro-4,4-dimethyl-2-thioxo-2H-3,1-benzoxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile, 5-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile, NSP 989

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About This Item

Empirische Formel (Hill-System):
C16H15N3OS
CAS-Nummer:
304853-42-7
Molekulargewicht:
297.37
MDL-Nummer:
MFCD18450396
UNSPSC-Code:
51111800
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 2 mg/mL, clear

Lagertemp.

−20°C

SMILES String

S=C1Nc2c(cc(cc2)c3[n](c(cc3)C#N)C)C(O1)(C)C

InChI

1S/C16H15N3OS/c1-16(2)12-8-10(4-6-13(12)18-15(21)20-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,21)

InChIKey

PYVFWTPEBMRKSR-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Non-steroidal progesterone receptor agonist
Tanaproget is a high affinity, high efficacy and selective orally available non-steroidal progesterone receptor agonist.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360FD

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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Analysenzertifikate (COA)

Lot/Batch Number

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Louis Allott et al.
EJNMMI radiopharmacy and chemistry, 4(1), 1-1 (2019-10-30)
The histological evaluation of estrogen receptor (ER) and progesterone receptor (PR) expression in breast cancer lesions from biopsy tissue can stratify patients to receive endocrine therapy. Furthermore, PR expression can predict response to selective estrogen receptor modulators (SERMs). Current immunohistochemical
Jody L Bapst et al.
Contraception, 74(5), 414-418 (2006-10-19)
This study aimed to evaluate the pharmacokinetics, pharmacodynamics and safety of the nonsteroidal progesterone receptor agonist, tanaproget. A randomized, double-blind, placebo-controlled, sequential-group study of ascending single doses of tanaproget was conducted in healthy, 25- to 45-year-old women on cycle days
Richard C Winneker et al.
Steroids, 73(7), 689-701 (2008-05-13)
Progesterone receptor (PR) modulators have evolved both structurally and mechanistically over the past half-century. Classical steroidal PR agonists continue to play an important role in women's health such as in oral contraception and post-menopausal hormone therapy whereas steroid-based PR antagonists

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