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SML0530

Sigma-Aldrich

Clonixin

≥98% (HPLC)

Synonym(e):

2-[(3-Chloro-2-methylphenyl)amino]-3-pyridinecarboxylic acid, CBA 93626, Chlonixin, Clonixic acid, Clonixin, Clonixine, NSC 335505, Sch 10304

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About This Item

Empirische Formel (Hill-System):
C13H11ClN2O2
CAS-Nummer:
17737-65-4
Molekulargewicht:
262.69
MDL-Nummer:
MFCD00864292
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825534
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 15 mg/mL, clear

Lagertemp.

room temp

SMILES String

Cc1c(Cl)cccc1Nc2ncccc2C(O)=O

InChI

1S/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18)

InChIKey

CLOMYZFHNHFSIQ-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Clonixin is a non steroidal anti inflammatory drug (NSAID) with analgesic properties. The compound has been reported to block prostaglandin synthesis, and to block inward calcium currents.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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L W Kissell et al.
Journal of dairy science, 95(12), 7151-7157 (2012-10-09)
The objective of this study was to determine if the plasma pharmacokinetics and milk elimination of flunixin (FLU) and 5-hydroxy flunixin (5OH) differ following intramuscular and subcutaneous injection of FLU compared with intravenous injection. Twelve lactating Holstein cows were used
J H Foreman et al.
Equine veterinary journal. Supplement, (43)(43), 17-20 (2013-03-02)
There are no refereed controlled documentations of the skeletal analgesic efficacy of different dosages of flunixin meglumine (FM). The objective of this experiment was to compare the efficacy of various dosages of FM with a negative control. The hypothesis was
Jeffrey M B Musser et al.
Journal of the American Veterinary Medical Association, 242(2), 205-208 (2013-01-02)
To investigate the disposition kinetics of flunixin meglumine when administered IV to budgerigars (Melopsittacus undulatus) and Patagonian conures (Cyanoliseus patagonus). Prospective cohort study. 8 adult Patagonian conures and 24 adult budgerigars. Injectable flunixin meglumine (50 mg/mL) was diluted to 10
C Donalisio et al.
Journal of veterinary pharmacology and therapeutics, 36(2), 130-139 (2012-06-26)
In this study, ex vivo assays were carried out in dairy cows to evaluate the anti-inflammatory effects of two nonsteroidal anti-inflammatory drugs: ketoprofen (KETO) and flunixin meglumine (FM). Twelve healthy Holstein dairy cattle were randomly allocated to two groups (n=6):
G Pugliesi et al.
Theriogenology, 78(2), 443-454 (2012-05-15)
The beginning of postluteolysis (progesterone, <1 ng mL(-1)) in heifers was targeted by using 8 h after ultrasonic detection of a 25% decrease in CL area (cm2) and was designated Hour 0. Flunixin meglumine (FM; n=10) to inhibit PGF2α secretion
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