SML0413

FQI1

≥98% (HPLC)

• Synonym(e): 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one
• Empirische Formel (Hill-System): C₁₈H₁₇NO₄
• CAS-Nummer: 599151-35-6
• Molekulargewicht: 311.33
• MDL-Nummer: MFCD03632583
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825408
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL (clear solution)
• Lagertemp.: 2-8°C
• SMILES String: O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1
• InChI: 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)
• InChIKey: YKSYGLXHLSPWLB-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). FQI1 inhibits LSF-dependent luciferase reporter expression, blocks proliferation in cancer cell lines, and induces apoptosis in liver cancer cells but is not toxic to primary hepatocytes. FQI1 also inhibits tumor growth in a mouse HCC xenograft model.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3