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SML0246

Sigma-Aldrich

Tirofiban hydrochloride monohydrate

≥98% (HPLC)

Synonym(e):

L 700462, MK 383, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine

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About This Item

Empirische Formel (Hill-System):
C22H36N2O5S·HCl·H2O
CAS-Nummer:
150915-40-5
Molekulargewicht:
495.07
MDL-Nummer:
MFCD07368623
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825256
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Optische Aktivität

[α]/D -10 to -18° (c=1, MeOH)

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

DMSO: >12 mg/mL at warmed to 60 °C

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

OC([C@@H](NS(CCCC)(=O)=O)CC1=CC=C(C=C1)OCCCCC2CCNCC2)=O.Cl.O

InChI

1S/C22H36N2O5S.ClH.H2O/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18;;/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26);1H;1H2/t21-;;/m0../s1

InChIKey

HWAAPJPFZPHHBC-FGJQBABTSA-N

Angaben zum Gen

human ... ITGA2B(3674) , ITGB3(3690)

Anwendung

Tirofiban hydrochloride monohydrate has been used as an αIIbβ3 integrin (glycoprotein IIb/IIIa) inhibitor for mouse induced pluripotent stem cell (iPSC) culture.

Biochem./physiol. Wirkung

Tirofiban hydrochloride is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. Blocks platelet aggregation and thrombus formation.
Tirofiban might cause thrombocytopenia.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Yu-Lun Tseng et al.
Toxicology and applied pharmacology, 364, 106-113 (2018-12-29)
Collagen and convulxin induce platelet aggregation through glycoprotein VI (GPVI)-FcRγ-Syk signaling pathway. In addition, fibrinogen induces platelet activation through integrin αIIbβ3-FcγRIIa-Syk signaling pathway. We previously reported that high concentrations of selective serotonin reuptake inhibitors (SSRI) reduce platelet aggregation induced by
C J Panebianco et al.
European cells & materials, 39, 211-226 (2020-05-13)
Back pain is a leading cause of global disability associated with intervertebral disc (IVD) pathologies. Discectomy alleviates disabling pain caused by IVD herniation without repairing annulus fibrosus (AF) defects, which can cause accelerated degeneration and recurrent pain. Biological therapies show
Yongxuan Liu et al.
Pakistan journal of medical sciences, 36(2), 54-58 (2020-02-18)
To investigate the therapeutic effect of tirofiban hydrochloride sodium chloride injection combined with cardiovascular intervention on acute myocardial infarction. Eighty-four patients with acute myocardial infarction who were treated in our hospital from April 2017 to May 2018 were divided into
Xia Hong et al.
Journal of clinical laboratory analysis, 30(2), 108-113 (2014-11-27)
Activated clotting time (ACT) has been successfully applied during percutaneous coronary intervention (PCI) to monitor the extent of thrombin inhibition and anti-coagulation from unfractionated heparin (UFH) aiming to reduce the incidence of thrombotic adverse events and hemorrhagic complications. And this
Inhibition of the integrin signal constitutes a mouse iPS cell niche.
Higuchi S, et al.
Development, Growth & Differentiation, 58(7), 586-599 (2016)
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