Direkt zum Inhalt
Merck
Alle Fotos(1)

Wichtige Dokumente

Gesamtdokumentation anzeigen

SML0185

Sigma-Aldrich

NQDI-1

≥98% (HPLC)

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C19H13NO4
CAS-Nummer:
175026-96-7
Molekulargewicht:
319.31
MDL-Nummer:
MFCD03265970
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825214
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

orange

Löslichkeit

DMSO: ≥5 mg/mL (warmed to 60° C)

Lagertemp.

2-8°C

SMILES String

CCOC(=O)C1=C2c3ccccc3C(=O)c4cccc(NC1=O)c24

InChI

1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)

InChIKey

UFJGFNHRMPMALC-UHFFFAOYSA-N

Anwendung

NQDI-1 was used to study LPS-induced activation and role of ASK1 and p38 in anti-inflammatory cytokine production by macrophages.

Biochem./physiol. Wirkung

NQDI-1 inhibits the activation of caspase-3 and prevents cell death by apoptosis. It is neuroprotective and prevents the ROS-induced apoptosis of the neurons.
NQDI-1 is an inhibitor of apoptosis signal-regulating kinase (ASK1), Ki = 500 nM. NQDI-1 shows little or no inhibitory activity against Aurora A or ROCK kinases, or several receptor tyrosine kinases.

Leistungsmerkmale und Vorteile

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
075M4616V
101M4604V

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

So Yeong Cheon et al.
Frontiers in molecular neuroscience, 10, 261-261 (2017-09-01)
Inflammation is implicated in ischemic stroke and is involved in abnormal homeostasis. Activation of the immune system leads to breakdown of the blood-brain barrier and, thereby, infiltration of immune cells into the brain. Upon cerebral ischemia, infiltrated macrophages and microglia
Youguang Luo et al.
Oncotarget, 7(46), 75155-75164 (2016-09-23)
Pancreatic cancer has an extremely grim prognosis, with an overall 5-year survival rate less than 5%, as a result of its rapid metastasis and late diagnosis. To combat this disease, it is crucial to better understand the molecular mechanisms that
Koji Nomura et al.
Neuroscience letters, 549, 163-167 (2013-06-08)
Reactive oxygen species (ROS) are believed to be involved in many forms of neurodegeneration, including ischaemic infarct damage and Alzheimer's disease. Despite the known involvement of p38 and JNK MAP kinases in mediating apoptosis and cell death in a variety
Xi Huang et al.
International journal of cancer, 146(7), 1963-1978 (2019-08-08)
E3 ubiquitin ligases primarily determine the substrate specificity of the ubiquitin-proteasome system and play an essential role in the resistance to bortezomib in multiple myeloma (MM). Neural precursor cell-expressed developmentally downregulated gene 4-1 (NEDD4-1, also known as NEDD4) is a
Aiko Tanaka et al.
Biochemical and biophysical research communications, 493(1), 468-473 (2017-09-09)
Free fatty acids not only play a role in cell membrane construction and energy production but also exert diverse cellular effects through receptor and non-receptor mechanisms. Moreover, epidemiological and clinical studies have so far suggested that polyunsaturated fatty acids (PUFAs)
Alle zugehörigen Dokumente anzeigen

Artikel

Mitogen-activated Protein Kinases (MAPKs)

The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.