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SML0175

Sigma-Aldrich

Pyrovalerone hydrochloride

≥98% (HPLC)

Synonym(e):

1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride, Centroton, F 1983, Sp 1059, Thymergix

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About This Item

Empirische Formel (Hill-System):
C16H23NO·HCl
CAS-Nummer:
1147-62-2
Molekulargewicht:
281.82
EG-Nummer:
214-556-9
UNSPSC-Code:
41116107
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

drug control

psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

Farbe

off-white to light brown

Löslichkeit

H2O: ≥5 mg/mL at 60 °C

Lagertemp.

2-8°C

InChI

1S/C16H23NO.ClH/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14;/h7-10,15H,3-6,11-12H2,1-2H3;1H

InChIKey

MWRACNBZNVAJHE-UHFFFAOYSA-N

Anwendung

Pyrovalerone hydrochloride may be used in dopamine-mediated cell signaling studies.

Biochem./physiol. Wirkung

Pyrovalerone hydrochloride is a rapidly-absorbed psychostimulant. It belongs to the class of synthetic cathinones often used as performance-enhancing agent by athletes before being banned.
Pyrovalerone is a norepinephrine-dopamine reuptake inhibitor (NDRI) that acts as a CNS stimulant.

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302,H336

Gefahreneinstufungen

Acute Tox. 4 Oral - STOT SE 3

Zielorgane

Central nervous system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Jane M Prosser et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(1), 33-42 (2011-11-24)
Synthetic cathinones have recently emerged and grown to be popular drugs of abuse. Their dramatic increase has resulted in part from sensationalized media attention as well as widespread availability on the Internet. They are often considered "legal highs" and sold
C Héron et al.
European journal of pharmacology, 264(3), 391-398 (1994-11-03)
We have studied the ability of various uptake blockers to protect the dopamine neuronal carrier labeled with [3H]GBR 12783 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-(propenyl)-piperazine) against N-ethylmaleimide-induced alkylation, using membrane preparations obtained from rat striatum. Pure uptake inhibitors such as mazindol, pyrovalerone, nomifensine and methylphenidate
H S Shin et al.
Journal of analytical toxicology, 20(7), 568-572 (1996-11-01)
Detection and identification of pyrovalerone and its metabolite, a hydroxylated product, are described. Their identities were confirmed by comparing their mass spectra and gas chromatographic retention times with those of the synthetic standards. The analytical method of pyrovalerone and its
The metabolism of pyrovalerone hydrochloride.
W Michaelis et al.
Journal of medicinal chemistry, 13(3), 497-503 (1970-05-01)
D S Lho et al.
Journal of chromatography. B, Biomedical applications, 687(1), 253-259 (1996-12-06)
Pyrovalerone and its hydroxylated metabolite have been identified by gas chromatography-mass spectrometry in rat urine and plasma. A sensitive gas chromatographic method for the quantitative analysis of pyrovalerone in rat urine and plasma is described. The method also permits the
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Artikel

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