SCP0221
Procaspase 3 Substrate
≥95% (HPLC), lyophilized
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About This Item
Empirische Formel (Hill-System):
C29H34N5O12S1
Molekulargewicht:
676.67
UNSPSC-Code:
12352200
NACRES:
NA.32
Empfohlene Produkte
product name
Procaspase 3 Substrate,
Assay
≥95% (HPLC)
Form
lyophilized
Zusammensetzung
Peptide Content, ≥77%
Lagerbedingungen
protect from light
Lagertemp.
−20°C
Amino Acid Sequence
Ac-Glu-Ser-Met-Asp-AFC
Anwendung
Procaspase 3 Substrate (Ac-ESMD-AFC) contains the target sequence for the proteolytic production of the p17 subunit of caspase 3 from its precursor (procaspase). Ac-ESMD-CHO inhibits this activity. Ac-ESMD-AFC may be used in comparison with other procaspase substrate and inhibitor peptides to differentiate proteolytic activity used for procaspase processing.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Dominique Le Goff et al.
Reproductive toxicology (Elmsford, N.Y.), 21(3), 329-334 (2005-11-02)
The aim of the present study was to determine whether or not apoptosis occurs in Sertoli cells in presence of 25-hydroxycholesterol, an oxysterol derived from cholesterol-containing foods or endogenous oxidation. Here, we provide evidence that 25-hydroxycholesterol can induce cultured Sertoli
Johnson Agniswamy et al.
The FEBS journal, 274(18), 4752-4765 (2007-08-19)
Many protein substrates of caspases are cleaved at noncanonical sites in comparison to the recognition motifs reported for the three caspase subgroups. To provide insight into the specificity and aid in the design of drugs to control cell death, crystal
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro.
Z Han et al.
The Journal of biological chemistry, 272(20), 13432-13436 (1997-05-16)
The apoptotic cysteine protease, caspase-3, is expressed in cells as an inactive 32-kDa precursor from which 17 kDa (p17) and 12 kDa (p12) subunits of the mature caspase-3 are proteolytically generated during apoptosis. Two amino acid sequences, ESMD downward arrowS
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