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SCP0200

Sigma-Aldrich

Neuromedin N

Synonym(e):

NMN-125, NN, NT/N, NmN

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About This Item

Empirische Formel (Hill-System):
C38H63N7O8
Molekulargewicht:
745.95
UNSPSC-Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

Form

lyophilized

Zusammensetzung

Peptide Content, ≥65%

Lagerbedingungen

protect from light

UniProt-Hinterlegungsnummer

P30990

Lagertemp.

−20°C

Angaben zum Gen

human ... NTS(4922)

Amino Acid Sequence

Lys-Ile-Pro-Tyr-Ile-Leu

Biochem./physiol. Wirkung

Neuromedin N is a hexapeptide that is related to neurotensin. Its precursor, proneuromedin N, is expressed in the adrenals, brain, gut and also in several cancers. In myoelectric activity, it has been reported to act in a similar manner as neurotensin, at a lesser degree of potency. Neuromedin N has been shown to increase the chemotaxis capacity of mouse lymphocytes and to modulate function of the hypothalamo-pituitary-adrenocortical axis in rats. Neuromedin N has been proposed to exert its actions via increase in intracellular Ca2+ concentration, although this is uncertain.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model.
Wakabayashi-Nakao K
Oncology Reports, 28(4), 1181-1186 (2012)
J J Garrido et al.
Regulatory peptides, 41(1), 27-37 (1992-09-03)
The action of neurotensin and related peptides has not been yet studied on lymphocytes, although there are studies indicating the stimulative action of neurotensin, a peptide first isolated from bovine hypothalamus, on different functions of phagocytic immune cells. The present
Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases.
Checler F
European Journal of Pharmacology, 126(3), 239-244 (1986)
L K Malendowicz et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 47(1), 41-45 (1995-01-01)
The effects of a subcutaneous bolus injection of 2 micrograms neurotensin (NT) or neuromedin N (NMN) on the function of the hypothalamo-pituitary-adrenocortical axis were investigated in both normal and cold-stressed rats. The blood concentrations of ACTH, corticosterone (B) and aldosterone
E B Binder et al.
Pharmacological reviews, 53(4), 453-486 (2001-12-06)
Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential
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