SBR00121

Amphotericin B water soluble

from semisynthetic, powder

• Synonym(e): AmB, Amphotericin
• Empirische Formel (Hill-System): C₅₁H₈₂N₂O₁₉
• Molekulargewicht: 1027.20
• UNSPSC-Code: 51302401

Eigenschaften

• Biologische Quelle: fermentation/recombinant; semisynthetic
• Qualitätsniveau: 200
• Assay: ≥90% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: light yellow to very dark yellow, to very dark brown
• Wirkungsweise: cell membrane | interferes
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Eignung: fungi; yeasts
• InChI: 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• InChIKey: APKFDSVGJQXUKY-INPOYWNPSA-N

Beschreibung

Allgemeine Beschreibung

Amphotericin B is a polyene antifungal antibiotic which has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Amphotericin B water soluble is a synthetic derivative of AmB that preserves the antifungal activity but is highly miscible in water up to 100 mg/mL.

Biochem./physiol. Wirkung

Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. Antimicrobial spectrum: Includes fungi and yeast It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium. Amphotericin B is most effective against fungi and yeast.

Leistungsmerkmale und Vorteile

Easily soluble in water up to 100mg/mL
Animal component free
Tested for cell toxicity
Aseptically packaged
Can be 0.2µm filtered

Angaben zur Herstellung

Amphotericin B water soluble can be directly dissolved in the media to a working concentration of 2.5 mg/L.

Sonstige Hinweise

Product is sensitive to light.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H372
• P-Sätze: P260 - P264 - P270 - P314 - P501
• Gefahreneinstufungen: STOT RE 1
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable